Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"MSH2"”.
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MSH2 nuclear localization and MMR apoptotic response to DNA damage.
… on the type of damage. Nuclear influx of MSH2 may be part of the repair-independent mechanism. Results from confocal microscopy and fluorescent linked immunosorbent assays showed both a corollary movement of MSH2 with the MMR repair protein EXO1, as well as an ability of the two proteins …
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Characterizing Chromosomal Aberrations in Cells Deficient for Both ATM and MSH2
… mutated (ATM) and mutS homologue 2 (MSH2) are important DNA repair proteins that participate in DNA repair pathways to maintain genomic integrity. Mice deficient for ATM and MSH2 mice are viable. However, <em>ATM<sup>-/-</sup></em> mice show growth retardation, neurological defects, …
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Auditory Processing Deficits in MSH2-KO mice are linked to Aberrant Inhibitory Neuron Function in the Thalamic Reticular Nucleus
… DNA repair factor is Mut-S Homolog 2 (<em>Msh2</em>), which corrects base-base mismatches and insertion/deletion loops. In humans, defects in this repair pathway are linked to diseases that have severe neurological pathologies. These include Lynch syndrome, Huntington’s disease and …
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Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome
… of the DNA mismatch repair (MMR) genes, such as MSH2. MMR is a DNA damage repair pathway involved in the removal of base mismatches and insertion/deletion loops, caused by several endogenous and exogenous factors. Loss of MMR through somatic alteration of the wild-type MMR allele in LS results in …
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Identification of Mitochondrial Defects and Metabolic Consequences in Lynch Syndrome-Related Endometrial Cancer
… in DNA mismatch repair genes including <em>MSH2</em>, carries a 60% lifetime risk of developing endometrial cancer (EC). Mismatch repair deficiency (MMRd) causes hypermutability, which is assumed to be the main driver of LS-related EC development. However, incomplete penetrance of EC …
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The Role of Arabidopsis thaliana Mismatch Repair Proteins in Meiotic Recombination
… thaliana this includes three MSH heterodimers (MSH2-MSH3, MSH2-MSH6 and MSH2-MSH7) that recognise mismatched nucleotides and have demonstrated roles in repressing meiotic crossovers in hybrid plants. To further investigate the meiotic function of MMR genome-wide, I generated a series of msh2 …
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Mechanism of acquired temozolomide resistance in glioblastoma
… in the mismatch repair (MMR) components MSH2 and MSH6. The modest decrease in MSH2, and relatively modest decrease in MSH6, did not seem sufficient to account for the very large increase in TMZ resistance. However, shRNA-mediated modulation of MSH2 and MSH6 levels in vitro confirmed that …
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Regulation und funktionelle Analyse der menschlichen Mismatchreparaturgene /-proteine am speziellen Beispiel von hMSH2
… Erkrankung assoziiert. Der Mechanismus über den MSH2 an der Karzinomentwicklung beteiligt ist, sind Defekte in der DNA-Reparatur. Es konnte gezeigt werden, dass Mutationen in den kodierenden Regionen dieses Gens direkt in die Mikrosatelliteninstabilität involviert sind. Generell ist MSH2 ein Teil …
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AN EXAMINATION OF BINDING DIFFERENCES AMONG MISMATCH REPAIR RECOGNITION PROTEINS WITH MISMATCH AND CISPLATIN DAMAGED DNA
… examine these models, E. coli MutS, S. cerevisae MSH2-MSH6, and MSH2-MSH3 were expressed to perform fluorescence anisotropy binding experiments and to crystallize the proteins in complex with cisplatin damaged DNA for comparison to mismatch DNA binding. All three mismatch repair (MMR) recognition …
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Targeted Drug Discovery: Targeting a Specific Conformation of MutS/MSH Proteins with Small Molecules
… identify small molecules that will interact with MSH2/MSH6 and induce MMR-dependent damage signaling pathway that has been shown to be p53- and ATM-independent. Utilizing molecular dynamics simulations and autodocking experiments, databases were searched for commercially available compounds that …
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Comparative Morphological and Immunohistochemical Analysis of Benign and Malignant Epithelial Colon Tumors // Сравнителен морфологичен и имунохистохимичен анализ на бенигнени и малигнени епителни тумори на дебелото черво
… експресия на протеини APC, p53, SMAD4, MSH2 и BRAF при доброкачествени и злокачествени епителни тумори на дебелото черво във връзка с клинико-морфологичните показатели и ролята им в туморната инициация и прогресия. Получихме следните резултати: с редуциране площта на експресия на АРС …
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Visualizing the One-Dimensional Diffusion of DNA Mismatch Repair Proteins at the Single-Molecule Level
… searches along DNA by the protein complexes Msh2-Msh6 and Mlh1-Pms1 in order to locate and remove mispaired bases. The details of these critical processes remain poorly understood, largely due to a lack of experimental methods capable of probing these dynamic processes. A custom total …
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Lessons from a pilot study of screening for upper tract urothelial cell carcinoma in Lynch Syndrome
… screened, 86 had an MLH1 mutation and 2 had an MSH2 mutation. Eleven of the 12 patients who had microscopic haematuria were female. 10 patients had urinary tract infections. One patient had follicular cystitis and another had a simple renal cyst. No patients had hydronephrosis on ultrasound. All …
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The role of deficient mismatch repair system in Lynch syndrome and the increased risk of colorectal cancer
… contained the DNA mismatch repair genes, MSH1, MSH2, MSH6, PSM1, and PMS2 (Zhang et al. 2015. Specifically, chromosome 2 was found to contain the genes MSH2, MSH6, and PSM2, chromosome 3 contained the gene MLH1, and chromosome 7 contained the gene PMS2 (Zhang et al., 2015). In addition to the …
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Mismatch Repair Protein-Dependent Cytotoxic Signaling In Cells Treated With The Cancer Chemotherapeutic Cisplatin
… The MMR protein complex MutSα (consisting of the MSH2 and MSH6 proteins) binds to CDDP-DNA adducts and initiates MMR protein-dependent cell death in cells treated with CDDP; however, the molecular events underlying this death were previously unclear. MMR proteins have been suggested to be …
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Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome
… mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). The identification of MMR defective colon cancer is clinically relevant for diagnostic, prognostic and potentially also for treatment-predictive purposes. The aims of this thesis were to validate the application of the MMR index …
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The Evolution of Glioblastoma: A Single Case Study
… we observed disruptive mutations of MSH6, MSH2, PMS2 and MLH1 all of which are crucial to the MMR pathway. The pattern of mutations of these genes varied between the samples taken from the second recurrence, however, all three samples showed hypermutation. This suggests that the …
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Genomics of Lynch syndrome and Constitutional mismatch repair deficiency syndrome
… of the mismatch repair (MMR) genes e.g. MLH1, MSH2, MSH6 and PMS2 cause the dominant adult cancer syndrome termed Lynch syndrome (or hereditary non-polyposis colorectal cancer). In our South African cohort, the MLH1 exon 13 c.1528C>T mutation is the most common Lynch syndrome-causing variant in …
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