Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"MS-275"”.
-
Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… vitro metabolism and plasma protein binding of MS-275, a novel histone deacetylase inhibitor, in patients with solid tumors and lymphomas. A validated LC/MS assay was developed to quantitate MS-275 in plasma, human liver microsomes and urine. The pharmacokinetic (PK) evaluation was done using a …
-
The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… effects of the histone deacetylase inhibitor, MS-275, on the Fas signaling pathway and susceptibility of osteosarcoma (OS) to Fas ligand (FasL)-induced cell death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is inversely correlated with their …
-
Induced Gene Expression In Bladder Cancer: Kindlin-2 And Metallothionein-1x
… with bladder cancer. Metallothionein isoforms 1 & 2 (MT I/II) are over-expressed in high-grade muscle-invasive bladder cancers, and in one study, MT-1X showed increased levels of expression compared to the other isoforms. The main goal of the MT-1X study was to investigate the mechanism by …
-
Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… Chapter 1 reviews the transcriptional mechanisms involved in the memory formation, including the contribution of chromatin modification by acetylation of histone proteins. Mutating the histone acetyltransferase CREB-binding protein (CBP) impairs long-term memory formation, and pharmacologically …
-
Can changes in SR protein acetylation affect alternative splicing?
… (HDAC) inhibition, using the HDAC inhibitors MS-275 and SAHA. RNA from treated cells was isolated for use with RT-PCR arrays developed by Peter Stoilov. Western blotting was used to determine efficacy of HDAC inhibitors on total cellular acetylation. The future goal is to understand how …