Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MRTF-A"”.
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… and its Myocardin Related Transcription Factor (MRTF) coactivators during development. I present here my studies on the functions of MRTFs during brain and muscle development. First, I show that MRTF-A and -B redundantly control neuronal migration and neurite outgrowth during brain development. …
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The Extended Role of the Molecular Chaperone CCT
… such as actin, via the transcription activator MRTF-A. Cells depleted of CCTε have an increased SRF-mediated transcription in an SRF-luciferase gene reporter system. Monomeric CCTε was shown to interact directly with MRTF-A and the interaction site was identified as the apical domain of CCTε and …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… the myocardin related transcription factor A (MRTF-A)/serum response factor (SRF) signaling axis as required for VF myofibroblast activation. We demonstrate the therapeutic potential of MRTF-A/SRF inhibition across in vitro and in vivo models of VF scarring. In parallel, we show that decorin …
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Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
… Myocardin-Related Transcription Factor A (MRTF-A) localization. However, ultracentrifugation assays showed large unpolymerized actin fractions, suggesting that the filaments are brittle. In contrast, <em>Acta2<sup>+/- R258C TG</sup></em> SMCs are less well-differentiated, with pools of …
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ROLE OF FORMIN FHOD1 IN THE ACTIN PEDESTAL FORMATION
… infection outcomes, i. e. pedestal formation and MRTF-A translocation differ in different cell types.
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… by myocardin-related transcription factor A (MRTF-A/MKL1) nuclear translocation. The second aim explores the effects of mechanical unloading (simulated microgravity) on key adipocyte functions and actin cytoskeletal remodeling. This study demonstrated that mechanical unloading enhances …