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Showing 1 to 11 of 11 for “"MRP4"”.
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MRP4-Dependent Regulation of Fibroblast Migration
… cell migration. Multi-drug resistance protein 4 (MRP4), is a member of the large family of ATP binding cassette (ABC) transporter proteins, that localizes to the plasma membrane and functions as a nucleotide efflux transporter and thus plays a pivotal role in the regulation of intracellular cyclic …
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Mrp4 Is a Crucial Regulator of Testosterone Biosynthesis
… role of multidrug resistance protein 4 (Mrp4) in the testes is unknown. It was discovered that Mrp4 is expressed primarily in mouse and human Leydig cells; however, there is no current evidence that Mrp4 regulates testosterone biosynthesis. The role of Mrp4 was investigated in Leydig …
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Testing Whether MRP4 (a cAMP Efflux Pump) and the Beta 2 Andrenergic Receptor (an Upstream Regulator of cAMP Signaling Pathways
<p>Background and Aim: MRP4/ABCC4 is an ABC transporter that can efflux the second-messenger, cAMP, from cells. MRP4 has a PDZ interacting motif at its carboxy terminal end through which it binds to scaffolding proteins NHERF1 and PDZK1. Previous studies have shown that PDZK1 serves as a scaffold …
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Einfluss der löslichen Guanylylzyklase auf die Expression der cGMP-Exporter MRP4 und 5 in humanen Melanomzellen unter Hypergravitationsbedingungen
… (sGC) on the hypergravity-induced expression of MRP4/5, endothelial and inducible nitric oxide synthase (e/iNOS) and particulate GC (GC-A/B) in the non-metastatic 1F6 melanoma cell line was studied by silencing the mRNA-expression of the sGCb1 subunit through siRNA-transfection. The data show an …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… lines. By western blot analysis we demonstrated MRP4 and Pgp expression in neuroblastoma cell lines relatively resistant to topotecan (e.g., NB1691), but not in cell lines sensitive to topotecan (e.g., NB1643). In contrast, MRP1, MRP2, and breast cancer resistance protein (BCRP) expression did …
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Differente Expression der Multidrug-Resistenz-Proteine 4/5 in nicht und stark metastasierenden Melanomzellen unter Hypergravitationsbedingungen
… space preventing cells from toxification. MRP4 and 5, on which this investigation is focused, particularly mediate nucleoside-analogue export, i.e. guanosine 3´, 5´-cyclic monophosphate (cGMP) and conjugated nucleosides. cGMP plays an important signaling role in melanocytic physiology, …
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Molecular and Functional Analyses of Transport Proteins for Organic Anions
… mediated by the export proteins Mrp2 and Mrp4. In contrast to transport of the Mrp2-substrate fluorescein-methotrexate (FL-MTX), transport is not regulated by proteinkinase (PK) A, and PKC. For better characterization of kinetic parameters I studied transport of fluo-cAMP in membrane …
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Untersuchung der Genexpression von ABC- und SLC-Transmembranproteinen mit Beteiligung am aktiven Transport von Antigenen, Eikosanoiden und Zytostatika beim malignen Melanom
… expression levels were detected for MRP1, MRP2, MRP4, OATP3A1 and the still functionally uncharacterized OATP5A1. We could also show a down-regulation of TAP1. TAP1 mediates antigen presentation via MHC-I. MRP can confer drug resistance by decreasing the intracellular drug concentration. One …
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Hypergravitationsinduzierte Effekte auf cGMP-Konzentration humaner Melanozyten und Melanomzellen
… transport by the multidrug resistance proteins MRP4 and MRP5. Importantly, expression and stimulation of soluble guanylyl cyclase isoform by a nitric oxide donor and of the membrane isoforms by natriuretic peptides were not changed by hypergravity in comparison to 1g controls. Thus, the …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… Cassette (ABC) transporters Bcrp1, P-gp, and Mrp4 in CNS penetration of molecularly targeted agents under investigation for treatment of malignant glioma. We choose the specific inhibitor of epidermal growth factor receptor (EGFR), erlotinib (TarcevaTM), and the specific inhibitor of …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… suppression of OCT2, OATP4C1, MATE2-K, MRP2, MRP4, and PEPT2), but these did not translate into measurable changes in OAT1–3, OAT4, OCT2, or OCTN1 activity. These findings argue against physiologic PRH concentrations as the primary driver of increased OAT-mediated secretion during pregnancy …