Global ETD Search
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Showing 1 to 19 of 19 for “"MRP1"”.
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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2
… of multidrug resistance protein 1 (MRP1), a plasma membrane ATP-binding cassette (ABC) transporter, is associated with high-risk neuroblastoma. While it is known that MRP1 transports multiple neuroblastoma chemotherapeutic agents out of the cell in a glutathione (GSH)-dependent …
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Modulation of the Expression of Multidrug Resistance Proteins by Sulforaphane and Erucin
… of target genes. Because SF and ER increased MRP1 expression at the mRNA level, we investigated the impact of these compounds on MRP1 transcription. Non-small cell lung cancer cells (A549) and human liver carcinoma cells (HepG2) were transfected with an MRP1-luciferase reporter gene and …
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Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
… including multi-drug resistance proteins (MRP1/MRP2) may be required for removal of HNE-SG. The combined role of GSTs with MRP1/2 was studied in stably transfected MCF7 and a HepG2 cell line model. Co-expression of GSTM1 + MRP1 leads to increased HNE-protein adducts formation and …
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Subcellular Localization and Activity of the Multidrug Resistance Protein 1
… the human multidrug resistance protein or MRP1. MRP1, like other members of the MDR transporter family, is thought to be expressed at the plasma membrane and decrease the intracellular accumulation of many different chemotherapeutic compounds. Unlike other MDR transporters, however, MRP1 is …
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Pharmacological modulation and manipulation of cancer drug resistance
… assays for their ability to overcome MRP1 and P-gp-mediated drug resistance. Two compounds were successful P-gp modulators in the DLKP-A cell line; the ditrifluoroacetyl resveratrol derivative, RBM15, and the macrocycle derivative, KG104. A panel of nine therapeutic agents were …
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Molecular and Functional Analyses of Transport Proteins for Organic Anions
… be mediated by Mrp4, whereas a participation of Mrp1 is likely. Regulation of fluo-cAMP transport in rat CP is not mediated by PKA, PKC or mitogen activated PK (MAPK). ·Transport of Texas Red (TR) and FL-MTX was studied in CP of rat and spiny dogfish shark. Transport of TR across rat CP is a …
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Expression and function of drug transporters in primitive CML cells
… expression was reduced in CML CD34+ cells and MRP1 was detected at similar expression levels in both populations. All three drug transporters were expressed at the protein levels in CML CD34+ cells. It was determined that at therapeutic concentrations (5μM) IM and nilotinib both inhibited ABCG2 …
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Multidrug resistance proteins (MRP) transport the cytokine/nuclear protein High Mobility Group Box 1 (HMGB1) across membranes
… to belong to ABC C group. Overexpression of MRP1/ABCC1, MRP2/ABCC2 and MRP3/ABCC3 endows activated cells with the ability to secrete HMGB 1. Moreover, macrophages from Mrp1-1- mice have impaired HMGB1 exocytosis. I also suggest that HMGB1 is unfolded during its translocation. MRP transporters …
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Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
… in den Membran-Transportproteinen MDR1, MRP1, MRP2, MRP3 und BCRP auf die Pharmakokinetik und ausgewählte Nebenwirkungen des Zytostatikums Doxorubicin zu untersuchen. Dazu wurden die Plasmakonzentrationen von Doxorubicin und Doxorubicinol von 94 Krebspatienten durch HPLC analysiert. Die …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
… to decrease the drug resistance by inhibiting MRP1 utilizing high-content based assay in presence of calcein-AM as MRP1 substrate. Compounds <strong>MMAmix, MMA242, MMA132, MMA335, MMA337</strong> and<strong> MMA320</strong> showed potential inhibitory activity on <strong>MRP1</strong> with …
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The significance of aberrant phenotypes and multidrug resistance for evaluation of the dynamics of minimal residual disease in acute leukemia patients /
… of multidrug resistance related proteins (P-gp, MRP1) on the surface of leukemic cells and examining their function by detecting an accumulation of calcein within the cell. The response to treatment was assessed applying the original flow cytometric assay for minimal residual disease detection. …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… and multidrug resistance associated protein 1 (MRP1), which efflux many drugs used in neuroblastoma therapy, has been implicated in poor outcome in neuroblastoma. Therefore, the purpose of our studies was to determine the role of ABC transport protein expression in neuroblastoma resistance to …
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Sergančiųjų ūmine leukemija aberantinių fenotipų ir dauginio atsparumo vaistams nustatymas ir svarba vertinant minimalios liekamosios ligos dinamiką /
… of multidrug resistance related proteins (P-gp, MRP1) on the surface of leukemic cells and examining their function by detecting an accumulation of calcein within the cell. The response to treatment was assessed applying the original flow cytometric assay for minimal residual disease detection. …
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A feasibility study of chemosensitivity testing in primary cultures from malignant gliomas, and analysis of drug resistance mechanisms
… multiple drug resistance associated protein 1(MRP1), p53, Ki-67 and MGMT proteins. These profiles did not show any correlation between the factors analyzed and chemosensitivity to the five chemotherapeutic agents used. Functional studies of drug efflux pumps PGP and MRPI, performed on 5 …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… resistance associated proteins 1 and 2 (MRP1 and 2)/ABCC1 and 2 and breast cancer resistance protein (BCRP)/ABCG2 was initially studied in term human placenta, cultured primary trophoblast and BeWo and Jar trophoblast-like cell lines. Jar cells were found to be more similar to …
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NEW PREDICTIVE FACTORS IDENTIFIED BY MOLECULAR STUDY IN CHEMORESISTANT HUMAN AND CANINE MAMMARY CARCINOMA CELLS
… five cell lines were used and MDR1, BCRP, MRP1, MRP2 and MRP3 gene expression were assessed to evaluate the baseline expression of these multiple drug resistance genes. Then, these cells were subjected to an induced chemoresistance protocol using doxorubicin. The cell DNA was collected …
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Study of porphyrins and heterodimers targeting ABCG2 transporter and development of a multiplexed flow cytometric approach for detection of anti SARS-CoV-2 IgG, IgM and IgA
… já que não foi observada inibição em P-gP nem em MRP1. Porfirina 4B foi capaz de ressensibilizar células que superexpressam o transportador ABCG2. Estes achados reforçam a ideia de que substratos podem ser uma fonte privilegiada de estruturas para identificação de novos inibidores para …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… (cubilin, megalin), while inducing OCTN1 and MRP1/3. TNF-α reproduced the effects of IL-1β but only on OAT1–3. Functional assays showed concordant IL-1β-driven decreases in OAT1–3, OAT4, and OCT2 activity and increased OCTN1 activity. Mechanistic experiments with ERK, p38MAPK, JNK, and NF-κB …