Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"MRNA splicing"”.
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The evolution of mRNA splicing in mammals
… I describe investigations into the evolution of splicing in mammals. I first investigate a small class of alternative splicing events, tandem splice sites, and show how they are used to introduce and remove coding sequence in a species-specific manner. I then describe the generation and analysis …
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Algorithms for simulating human pre-mRNA splicing decisions
… ExonScan, to simulate constitutive human pre-mRNA splicing. ExonScan includes several models for splicing components, including splice sites, exonic splicing enhancers, exonic splicing silencers, and intronic splicing enhancers. I used ExonScan to test various aspects of human splicing, …
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Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins
… serine starvation induces dramatic changes in mRNA splicing. These effects are due, in part, to reduced translation of serine-rich proteins in serine-starved conditions, including the serine/arginine-rich splicing factor (SRSF) proteins that are known regulators of mRNA splicing. Indeed, we …
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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
… to cervical cancer. HPV-16 uses alternative splicing to regulate expression of early and late genes. HPV RNA elements and cellular factors control the expression level of viral proteins by regulating alternative splicing. This project was carried out to enhance our understanding of the …
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The role of U1 and snRNP in pre-mRNA splicing
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
… two separate pieces of work pertaining to pre-mRNA splicing in mammalian cells. The first part examines the regulation of the alternative splicing of the PKM gene in cancer cells, while the second part investigates the physical connections between the transcriptional apparatus and splicing …
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In Vivo Analysis of Pre-Mrna Splicing in Dicot Plant Nuclei
In vivo gene transfer experiments have suggested that the elements mediating intron recognition differ in monocot and dicot nuclei.
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Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species
… key steps in eukaryotic gene expression is pre-mRNA splicing, whereby intronic sequences are excised from immature pre-mRNA transcripts and the remaining exonic sequences are joined together. This process is catalyzed by the spliceosome, a large complex of proteins and RNAs. A variety of RNA …
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Role of SMU Homologues in Pre-mRNA Splicing During Maize and Arabidopsis Development
… either thenematode smu-1 or smu-2 genes affect splicing of the unc-52 pre-mRNA, and SMU-1 protein interacts with SMU-2 protein. In addition, human homologues of SMU-1 and SMU-2 proteins wereidentified from human spliceosome. Thus, animal SMU-1 and SMU-2 homologuesappear to play a role in …
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Regulated T cell pre-mRNA splicing as genetic marker of T cell suppression
Includes abstract. Includes bibliographical references.
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Characterizing population-level variation in mRNA splicing and implications for human genetic interpretation
Alternative splicing is when a single gene sequence gives rise to multiple RNA sequences. DNA mutations in this gene sequence can alter this process, shifting the relative usage of RNA sequences. This relative usage is called percent spliced in (PSI). Sometimes changes in PSI triggers a change in …
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Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing
… from a limited number of genes via alternative splicing, where one gene gives rise to multiple proteins. Alternatively spliced gene products, although crucial for normal physiology, are also linked to an increasing number of pathologies. Consequently, a growing focus is currently being placed on …
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The Role and Fate of Branch Site-U2 snRNA Interaction During Pre-mRNA Splicing
… dynamics underlying transitions during premRNA splicing, particularly during the catalytic phase, remain unclear despite our deep knowledge of spliceosome composition. The complex assembly phase that precedes catalysis, and the involvement of several motifs in multiple interactions along …
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Genome-wide survey and analysis of allele-specific mRNA splicing in human and mouse
This dissertation aims to examine allele-specific splicing in human and mouse using publicly available datasets. Such datasets, which have been generated from multiple tissue sources and from individuals of diverse backgrounds, are rich and cheap reservoirs of transcript isoforms resulting from …
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Essential Protein Factors in pre-mRNA splicing : A Structural Study by Nuclear Magnetic Resonance Spectroscopy
… that play important roles in eukaryotic RNA splicing. These results are discussed in Chapters 1 and 2, while biomolecular NMR techniques that were employed for the structure determination are outlined in Chapter 3. Materials and methods are described in Chapter 4. Chapter 1 presents the …
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Alternative Mrna Splicing Redefines The Landscape Of Commonly Dysregulated Genes Across The Acute Myeloid Leukemia Patient Population.
… to this disease. Here, I investigate pre-mRNA splicing events with significant variation and striking coregulation across distinct AML cohorts. I find that most splicing events are expected to alter the expression of a subset of AML-associated genes independent of known somatic mutations. …
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The requirement of glycoprotein C for natural infection and mRNA splicing of UL44 is conserved among the mardiviruses
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-08-01
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Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration
… their high cellular complexity. Alternative splicing (AS), the most common PTGRM, is a process by which the exons of a pre-mRNA are spliced into different arrangements to produce structurally and functionally distinct mature mRNAs thereby contributing to the transcriptome complexity. …
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Molecular analysis of wheat snRNAs
Pre-mRNA splicing is a complex event in which introns are removed and exons spliced together. This process is mediated by small ribonucleoprotein particles (snRNPs), formed from small nuclear RNAs (snRNAs) and their associated nuclear proteins.
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Su onkologinėmis ligomis siejamas pre-iRNR splaisingas: splaisingo veiksnių ir hipoksinės mikroaplinkos tyrimas /
… has been systematically increasing. As pre-mRNA splicing is a highly important process in regulating gene expression, it is not surprising that changes in splicing have been observed in many different diseases. Unfortunately, the reasons for the expression of disease-associated mRNA isoforms …
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