Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"MRN complex"”.
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THE FUNCTION OF MRN (MRE11-RAD50-NBS1) COMPLEX DURING WRN (WERNER) FACILITATED ATM (ATAXIA-TELANGIECTASIA MUTATED) ACTIVATION
… fork collapse. Because the Mre11-Rad50-Nbs1 (MRN) complex, a sensor of DSBs, is known to interact with WRN and ATM, we investigated whether the MRN complex mediates the WRN-dependent ATM pathway activation. In this study, we employed short-hairpin RNA to generate WRN- and Nbs1-deficient U-2 OS …
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How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?
… This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a multitude of downstream pathways such as DNA damage repair, cell cycle arrest, senescence and sometimes apoptosis. In …
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Characterization of a Novel 53BP1-Dependent Mechanism that Promotes Non-Homologous End Joining of Deprotected Telomeres by Increasing Chromatin Mobility
… have examined the roles of the Mre11/Rad50/NBS1 (MRN) complex, H2AX, MDC1, and 53BP1 in the NHEJ of dysfunctional telomeres. We have demonstrated that among these factors, 53BP1 is required for the fusion of telomeres, whereas the MRN complex, H2AX, and MDC1 only stimulate the efficiency of the …
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The interaction of CtIP with DNA damage response proteins
… vivo with DNA damage sensor proteins such as the MRN complex (Mre11, Rad50 and NBS1) and RPA70, signal transducer proteins such as the PIKK kinases ATM, ATR and SMG1 and the mediator proteins 53BP1 and MDC1. All of those proteins are involved in detecting and repairing double stranded or single …
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DNA damage responses in the context of the cell division cycle
… DNA damage responses by regulation of the GINS complex, and checkpoint activation by the prototypical checkpoint protein Rad9. Here, I show that mitotic cells treated with DNA break-inducing agents activate a ‘primary’ DDR, including ATM and DNA-PK-dependent H2AX phosphorylation and recruitment …
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ATM Deficiency -- A Multifaceted Defect in Lymphocyte Development
… the unrepaired ends in a stable post-cleavage complex possibly through the phosphorylation of components of the MRN complex. Secondly, in G1-phase lymphocytes, the ATM-dependent phosphorylation of histone H2AX inhibits the robust CtIP-dependent opening and resection of hairpin-sealed coding …
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Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes
… on a putative interaction of NAT10 with the complex of three proteins: MRE11, RAD50 and NBS1/NBN (MRN complex). This complex plays an important role in the sensing and repair of DNA double-strand breaks (DSBs), highly genotoxic lesions that can result in unrestrained cellular lethality or …
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Distinct DNA Damage Signaling in the Brain Distinguishes ATLD, NBS, and ATR-Seckel Syndrome
… Hypomorphic mutations in the Mre11/Rad50/NBS1 complex (MRN complex), which is required for efficient ATM activity, result in distinct syndromes. Ataxia-telangiectasia-like disease (ATLD) results from truncating mutations in Mre11 and presents with neurodegeneration similar to that observed in …