Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"MRN"”.
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Estudio de la ubicuitilación del complejo MRN mediada por SCF(bTrCP/FBXW7): implicaciones biológicas
… de las roturas de doble cadena es el complejo MRN (MRE11, RAD50 y NBS1), esencial para la identificación de las roturas, el reclutamiento de diversos factores de señalización y el procesamiento, todo ello encaminado a la reparación de las mismas. El complejo MRN también interviene en otros …
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THE FUNCTION OF MRN (MRE11-RAD50-NBS1) COMPLEX DURING WRN (WERNER) FACILITATED ATM (ATAXIA-TELANGIECTASIA MUTATED) ACTIVATION
… fork collapse. Because the Mre11-Rad50-Nbs1 (MRN) complex, a sensor of DSBs, is known to interact with WRN and ATM, we investigated whether the MRN complex mediates the WRN-dependent ATM pathway activation. In this study, we employed short-hairpin RNA to generate WRN- and Nbs1-deficient U-2 OS …
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Single-molecule studies reveal mechanisms of human DNA double-strand break repair
… (Ku) and the Mre11-Rad50-Nbs1 complex (MRN), respectively. Ku encircles the DNA ends and recruits other factors, such the kinase DNA-PKcs, to bluntly ligate the ends back together. In contrast, MRN along with the long-range nuclease Exo1 and helicase BLM digests the DNA to create long 3’ …
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How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?
… This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a multitude of downstream pathways such as DNA damage repair, cell cycle arrest, senescence and sometimes apoptosis. In …
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Variations in critical flicker frequency with intersensory stimulation in two modalities
… theory called the mutually recruitable neuron or MRN theory, suggests that both magnitude and direction of effect are functions of the intensity of primary and accessory stimuli. Empirical results in the context of this theory and of others are consistent with these suggestions [TRUNCATED]
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Molecular Mechanisms of Mitotic Spindle Assembly and Accurate Chromosome Segregation
… extracts and mammalian cells. I show that the MRN (Mre11, Rad50, and Nbs1) complex is required for metaphase chromosome alignment. Consistent with the result of my colleague using Xenopus egg extracts, disruption of MRN function by depleting Mre11 using an inducible shRNA system, or Mre11 …
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Quasimetric decision transformer: enhancing goal-conditioned reinforcement learning with structured distance guidance
… Embedding (IQE) and Metric Residual Network (MRN), and integrate them into DTs. Extensive evaluations on the AntMaze benchmark demonstrate that QuaD outperforms standard DTs, achieving state-of-the-art success rates and improved generalization to unseen goals. Our results suggest that …
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On the induction of temporal structure by recurrent neural networks
… (NARX) network and the multi-recurrent network (MRN). In addition to this, Echo State Networks (ESNs) are a relatively new class of recurrent neural network that do not suffer from the vanishing gradients problem and have been shown to exhibit state-of-the-art performance in tasks such as motor …
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Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes
… of three proteins: MRE11, RAD50 and NBS1/NBN (MRN complex). This complex plays an important role in the sensing and repair of DNA double-strand breaks (DSBs), highly genotoxic lesions that can result in unrestrained cellular lethality or genomic instability. During this project, I showed that …
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Characterization of a Novel 53BP1-Dependent Mechanism that Promotes Non-Homologous End Joining of Deprotected Telomeres by Increasing Chromatin Mobility
… have examined the roles of the Mre11/Rad50/NBS1 (MRN) complex, H2AX, MDC1, and 53BP1 in the NHEJ of dysfunctional telomeres. We have demonstrated that among these factors, 53BP1 is required for the fusion of telomeres, whereas the MRN complex, H2AX, and MDC1 only stimulate the efficiency of the …
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Investigation into the Effects of Wire Mesh on Tensile and Impact Properties of Fiber Metal Laminates
… tests. Samples were strained at arate of 2 mrn/min for tensile tests and impacted with enetgies of 10 to 40 J in l0 J increments for impact tests. It was found that the 6.67 N Q4 oz) ShieldStand <sup>®</sup> S with 2024-T3 aluminum alloy sheet samples performed best when compared to the …
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Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases
… in promoting EF-NHEJ is largely independent of MRN-dependent ATM activation, and completely independent of ROS-dependent ATM activation. We discover a novel N-terminal set of positively charged residues that we propose directly interact with the negatively charged DNA phosphate backbone adjacent …
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The interaction of CtIP with DNA damage response proteins
… vivo with DNA damage sensor proteins such as the MRN complex (Mre11, Rad50 and NBS1) and RPA70, signal transducer proteins such as the PIKK kinases ATM, ATR and SMG1 and the mediator proteins 53BP1 and MDC1. All of those proteins are involved in detecting and repairing double stranded or single …
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DNA damage responses in the context of the cell division cycle
… phosphorylation and recruitment of MDC1 and the MRN complex to damage sites. However, downstream DDR events and induction of a DNA damage checkpoint are inhibited in mitosis, with full DDR activation only ensuing when damaged mitotic cells enter G1. In addition, I provide evidence that induction …
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Information and sentiment in financial markets
… a new database, Refinitiv Machine Readable News (MRN). The resulting portfolio achieves an annualized Sharpe ratio of 3.96, significantly higher than that of a passive investment (as proxied by S&P 500 index) and dictionary method, which achieves a Sharpe ratio of 0.32 and 2.94 respectively. We …
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ATM Deficiency -- A Multifaceted Defect in Lymphocyte Development
… through the phosphorylation of components of the MRN complex. Secondly, in G1-phase lymphocytes, the ATM-dependent phosphorylation of histone H2AX inhibits the robust CtIP-dependent opening and resection of hairpin-sealed coding ends thereby preventing their aberrant resolution by alternative …
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Analysis of microtopography, vegetation, and active-layer thickness using terrestrial LIDAR and kite photography, Barrow, AK
… slope, and Melton’s Ruggedness Number (MRN). Landcover at each plot was classified using the Visible Vegetation Index (VVI), calculated from a series of high-resolution (~10 cm) kite photographs obtained in August 2012 by researchers from the University of Texas – El Paso. The …
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Analysis of microtopography, vegetation, and active-layer thickness using terrestrial LIDAR and kite photography, Barrow, AK
… slope, and Melton’s Ruggedness Number (MRN). Landcover at each plot was classified using the Visible Vegetation Index (VVI), calculated from a series of high-resolution (~10 cm) kite photographs obtained in August 2012 by researchers from the University of Texas – El Paso. The …
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Distinct DNA Damage Signaling in the Brain Distinguishes ATLD, NBS, and ATR-Seckel Syndrome
… mutations in the Mre11/Rad50/NBS1 complex (MRN complex), which is required for efficient ATM activity, result in distinct syndromes. Ataxia-telangiectasia-like disease (ATLD) results from truncating mutations in Mre11 and presents with neurodegeneration similar to that observed in A-T, but …
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Mechanisms of Telomere End Protection by TRF2
… iDDR inhibits ATM through an interaction with MRN, and another in which it recruits additional factors that disrupt the accumulation of 53BP1 downstream of ATM signaling. Additionally, Rap1, a shelterin component brought to the telomere by TRF2, suppresses cNHEJ. This may occur through binding …
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