Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"MRI contrast agent"”.
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Investigation of a Potential Macromolecular MRI Contrast Agent Prepared From PPI (G = 2, Polypropyleneimine, Generation 2) Dendrimer Bifunctional Chelates
… imaging of this complex resulted in a 52% contrast enhancement in the rat kidney following the agents' administration in vivo.
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The Development of a Novel Tumor -Specific MRI Contrast Agent Targeting the High Affinity Folate Receptor: In Vitro and in Vivo Specificity, Toxicity, and Biodistribution
The need to develop target-specific MRI contrast agents to aid in disease characterization remains highly essential. Here, we present a generation four polyamidoamine (PAMAM) dendrimer conjugated to folic acid that specifically targets the high affinity folate receptor (hFR) overexpressed on more …
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Studies of Solution Paramagnetic-Substrate Nuclear and Electron Intermolecular Interactions
… (DNP), and magnetic resonance imaging (MRI)) were used to study the attitude and dynamics of TEMPO (2,2,6,6-tetramethylpiperidinyloxy)-substrate systems and the relaxivity properties of water-soluble trimetallic nitride template functionalized endohedral metallofullerenes (TNT-fMF). The …
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The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.
… research study was the synthesis of an imaging agent, which could be used to non-invasively image atherosclerotic plaques via MRI. In order to achieve this, a library of peptide substrates designed to be substrate specific for either legumain or MMP-2/9 were synthesized. This was achieved via a …
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The Use of Ultrasound-Targeted Microbubble Destruction in Mediated Delivery of a Gadolinium Magnetic Resonance Imaging Contrast Agent Into Fibroblast Cells In Vitro
A method for delivering Gd-based MRI contrast agents by ultrasound-targeted microbubble destruction into fibroblast cells in vitro is presented. First, MRI contrast agents Gd-F-DOTP-ME and Gd-DOTA-4iBA are shown to associate with liposome microbubbles used as ultrasound contrast agents. Repeated …
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Quantification of blood Gd-DTPA levels : implications on dosing dGEMRIC
… magnetic resonance imaging of cartilage (dGEMRIC) is a novel technique that allows early diagnosis of osteoarthritis (OA). Under the current protocol, subjects are injected 0.2mmol of an MRI contrast agent (Gd-DTPA 2, Berlex Imaging, Wayne, NJ) per kilogram of body weight. Because the …
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MRT-Leberdiagnostik mit dem leberspezifischen Kontrastmittel Gd-EOB-DTPA
In a Phase III clinical trial the liver-specific MRI contrast agent Gd-EOB-DTPA was administered to 40 Patients. The substance showed very good tolerance. After intravenous bolus injection a non-specific vascular phase can be performed. After that liver-specific imaging is possible. Sensitivity and …
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Synthesis, Characterization, and Evaluation of Silica-Nanosphere-Based Contrast Agents for Biomedical Application
Following cytotoxicity studies, MRI contrast agents were ultimately introduced into the silica nanospheres for dual functionality. Gd-DTPA, a commonly used MRI contrast agent, was chosen as an appropriate candidate for initial study. Through an in vivo experiment using tadpoles, we demonstrated and …
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Utilization of TMV-TEMPO as an in Vivo MRI Sensor of ROS Production in Liver Inflammation and as a DNP Agent
Magnetic resonance imaging (MRI) is a powerful tool that can noninvasively generate exquisite images of soft tissues in living subjects for medical diagnostics. This PhD dissertation details the i) utility of a nitroxyl-modified tobacco mosaic virus (TMV) as an in vivo MRI contrast agent for …
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In Situe Synthesis of Iron Oxide within Polyvinylamine nanoparticles
… of biomedical applications, specifically as an MRI contrast agent. A method was developed for preparing ≈150 nm polyvinylamine (PVAm) nanoparticles containing iron oxide. These polymeric nanoparticles offer colloidal stability and reactive primary amines for drug conjugation or surface …
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Gadolinium Endohedral Metallofullerenes for Future Magnetic Resonance Imaging Contrast Agents
… next generation magnetic resonance imaging (MRI) contrast agents due to their significantly improved efficiency and safety, as well as multi-day body retention which allows for a longer surgery and observation compared to current contrast agents. In Chapter 1, I have reviewed the development …
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Liposome Encapsulated Manganese Chloride as a Liver Specific Contrast Agent for Magnetic Resonance Imaging
… encapsulated paramagnetic ion (Mn$\sp{2+}$) as a contrast agent for magnetic resonance imaging (MRI) of the liver. Previous work with liposomes had shown that liposomes were concentrated in the liver after intravenous injection. Uptake of the vesicles into tumors was shown to be negligible. This …
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Engineering genetically-encodable MRI contrast agents for in vivo imaging
Magnetic resonance imaging (MRI) is gaining recognition as a powerful tool in biological research, offering non-invasive access to anatomy and activity at high spatial and temporal resolution. However, the range of biological phenomena accessible to measurement by MRI is limited, due to a current …
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Understanding The Physics Of Magnetic Nanoparticles And Their Applications In The Biomedical Field
… a potential applicant for T1–T2 dual-modal MRI contrast agent. We have explored the interactions of BiFeO3 nanoparticles on live cells and the binding of FITC-conjugated Fe3O4 nanoparticles with artificial lipid membranes to investigate these materials as candidates in medical imaging. Taken …
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Investigation of NMR properties of gel volume change with magnetic resonance imaging
Ferromagnetic or supetparamagnetic particles as MRI contrast agent present many advantages for bringing about soft tissue contrast as compared to single-ion complexes. Based on the dynamic frequency scale 1/τ and the magnetic frequency scale δω (perturber strength) of the system the relaxation …
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The characterization of a mouse model of transient stroke using ex vivo MR microscopy and in vivo MR imaging
… therapeutic treatment of stroke. Currently, MR contrast agents have been widely used in clinics for disease diagnosis and treatment evaluation, and in basic research to achieve better anatomical structure visualization and to understand pathological mechanisms of various human diseases in animal …
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From the body to the brain: Studying drug delivery and physiological interactions using MRI
… and molecular magnetic resonance imaging (MRI), in combination with other tools. In a first project, we examined properties of the blood-brain barrier (BBB). The BBB is a highly selective collection of endothelial cells and tight junction proteins that restrict passage of extracerebral …
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Advancements in branched bottlebrush polymers for responsive, targeted imaging
… Specifically magnetic resonance imaging (MRI) and nearinfrared (NIR) fluorescent probes can be used in combination to visualize biodistribution and in vivo clearance rates. We reasoned that through the use of a nitroxide radical MRI contrast agent along with a NIR fluorophore it would be …
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The Design of Stable, Well-Defined Polymer-Magnetite Nanoparticle Systems for Biomedical Applications
… drug targeting and delivery, and for use as a MRI contrast agent. This work outlines a general methodology to design well-defined, stable polymer-magnetite complexes. Colloidal modeling was developed and validated to describe polymer brush extension from the magnetite core. This allowed for the …
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