Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"MRI Imaging"”.
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
… and recovery after stroke. Emerging clinical imaging evidence suggests that white matter degeneration, secondary neurodegeneration and inflammation in areas like the corpus callosum and thalamus after a middle cerebral artery stroke may contribute to cognitive decline. The aim of the current …
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Endoprosthetic growth module mechanism for the skeletally immature
… contain ferromagnetic materials which eliminate MRI imaging as a means of follow-up assessment. Thus, there is a need to develop a non-ferromagnetic device capable of carrying out frequent minor extensions comparable to natural growth. This dissertation details the design of an extendible …
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Surgical system for image-based stereotaxy in the rat
Currently there are no of MRI image-based stereotactic apparatus for target determination in the brain of animals. Until now, the only stereotactic devices for directing problems and electrodes in animal brains for neuroscience are based on dental and ear canal fixation and on skull based features …
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Diffusion Tensor Imaging in Pediatric Brain Tumor Patients
… we outline our efforts to introduce an advanced MRI imaging technique called Diffusion Tensor Imaging (DTI) to the pediatric brain tumor population. We discuss the theory and application of DTI as it was performed in a series of translational investigations at St. Jude Children’s Research …
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Theoretical and Computational Generalizations on Hyperthermia using Magnetic Nanoparticles including Optimization, Control, and Aggregation
… a multifunctional nano-material that allows for MRI imaging, intravenous-controlled drug movement, and hyperthermia. The objective of this study is to optimize and control IONP hyperthermia and cope with aggregation using Finite Element (FE) Modeling and statistical physics. The FE model is first …
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A Novel Device for the Treatment of Obstructive Sleep Apnea
… Hypopnea Index (AHI) in healthy volunteers. MRI Imaging on volunteers wearing the device proved the device does enlarge the airway by 60% - 80%. A finite element model of the tongue, soft palate and airway, with muscle fiber direction derived from Diffusion Tensor MRI, is implemented as a …
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Developing novel polymer architectures for applications In magnetic resonance imaging and self-assembly
… scaffolds for drug delivery, self-assembly, and imaging applications have attracted significant attention over the last several decades. As polymerization techniques become more sophisticated, it becomes possible to create polymeric architectures with increasing control over structure, molecular …
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Development of novel diagnostics and therapeutics for amyotrophic lateral sclerosis
… that was shown to be highly visible under MRI and preserved the functionality of the native TTC protein in vitro. Live animal MRI imaging and immuno fluorescent staining of the spinal cord showed that the conjugate was transported to the central nervous system (CNS) and localized in motor …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
… It demonstrates that, by using a novel MRI gene reporter system; OATP, and controlling its expression under a Myelin Basic Protein promoter, OPCs can take up gadolinium based contrast, and be detected using T1 weighted MRI imaging in vitro and ex vivo. Using a constitutively active …
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Multifunctional CuS Nanoparticles for Imaging Guided Photothermal Ablation Therapy
… can act as an efficient radiotracer for PET imaging, and can be used for photothermal ablation therapy using near-infrared laser irradiation (Zhou, Zhang et al. 2010). Based on these novel [64Cu]CuS NPs, we have designed and investigated two different types of NPs for targeting delivery and …
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Morphometric measurements of the retinal vasculature in ultra-wide scanning laser ophthalmoscopy as biomarkers for cardiovascular disease
Retinal imaging enables the visualization of a portion of the human microvasculature in-vivo and non-invasively. The scanning laser ophthalmoscope (SLO), provides images characterized by an ultra-wide field of view (UWFoV) covering approximately 180-200º in a single scan, minimizing the discomfort …
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Visualisation of chemistry in flow
… a combination of optical and magnetic resonance (MRI) imaging techniques. The coupling between reaction-diffusion and advection was studied in three distinct systems. Stationary flow-distributed oscillation (FDO) patterns, previously only observed in packed bed reactors, were produced in …
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Synthesis and Characterization of Well-Defined Heterobifunctional Polyethers for Coating Magnetite and Their Applications in Biomedicine Resonance Imaging
… as potential contrast-enhancement agents for MRI imaging. Thus, transverse NMR relaxivities of these complexes were studied as a function of chemical composition and nanostructure size and compared to commercial contrast agents. The amphiphilic polyether-magnetite nanoparticles were shown to …
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Probing the effect of microstructure on water diffusion in engineered or biological materials with MRI
… structure of muscles. Magnetic Resonance Imaging (MRI) is an effective non-invasive technology for studying water transport in biological or engineered systems, and has been increasingly used to probe water diffusion in muscle. Because of the disparity between the length scales over which …
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Transparent neural interfaces for simultaneous electrophysiology and advanced brain imaging
Imaging and electrophysiology are the most fundamental tools in neuroscience research. On the one hand, optical imaging can target specific molecules with high spatial resolution *in vitro* and *in vivo*. Spectroscopic techniques like magnetic resonance imaging (MRI) can access deep regions of the …
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Block and Graft Copolymers Containing Carboxylate or Phosphonate Anions
… and used these polymers as carriers for both MRI imaging agents and cationic drugs. To enhance the capabilities of those carriers in tracking and crosslinking, we have designed, synthesized and characterized amine functionalized PEO-b-PAA copolymers. First, heterobifunctional poly(ethylene …
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Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
… 3) through the development of a novel habitat imaging method to identify treatment specific changes in the tumor draining lymph node, and the development of a hybrid agent-based model (ABM) to test cancer cell flow mediated invasion in brain cancer. Herin the work showed that carboplatin …
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Disease mechanisms and markers of progression in cerebral small vessel disease
… a cohort of patients with SVD undergoing PET-MRI imaging, phlebotomy and neuropsychometric testing. Results <br>WMHs typically expand at 2.50 ± 3.02 cc/year in patients with SVD and this is significantly more likely in patients with hypertension and who currently smoke. I found only 12/417 …
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Accelerating magnetic resonance imaging by unifying sparse models and multiple receivers
Magnetic resonance imaging (MRI) is an increasingly versatile diagnostic tool for a variety of medical purposes. During a conventional MRI scan, samples are acquired along a trajectory in the spatial Fourier transform domain (called k-space) and the image is reconstructed using an inverse discrete …
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Novel mechanisms of DC and kilohertz electrical stimulation
… across the blood-brain barrier using an advanced MRI imaging technique in a healthy population to investigate effect of tDCS stimulation on neurovascular units.</p> <p>The neuronal membrane has a well-established low pass filtering characteristic. This feature attenuates the sensitivity of the …
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