Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"MRD"”.
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Clinical Impact of A Highly Sensitive Next-Generation Sequencing Measurable Residual Disease Assay In Patients With Acute Lymphoblastic Leukemia
<p>Measurable residual disease (MRD) is highly prognostic for relapse and overall survival (OS) in acute lymphoblastic leukemia (ALL), although many patients with apparent “MRD negativity” by standard assays still relapse. We evaluated the clinical impact of a highly sensitive next-generation …
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Eficacia de una maltodextrina resistente a la digestión sobre el tiempo de tránsito colónico en sujetos sanos.
… como la maltodextrina resistente a la digestión (MRD). Por tanto, se realizó un estudio aleatorizado, controlado con placebo y doble ciego para evaluar los efectos de la MRD en el tiempo de tránsito colónico (TTC), la frecuencia defecatoria, el volumen de las heces, la consistencia de las heces y …
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Electrorotation and Dielectric Profiling: Advanced Strategies for Detecting Minimal Residual Disease in Multiple Myeloma
… e persistenza. La malattia minima residua (MRD) è un fattore prognostico cruciale, con la negatività della MRD fortemente correlata a una maggiore sopravvivenza libera da progressione (PFS) e sopravvivenza globale (OS). Inoltre, la valutazione della MRD attraverso le plasmacellule clonali …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… adipokine profiles contribute to weight gain and MRD risk. To achieve this weight status and BMI was recorded and blood plasma was tested using human adipokine arrays at diagnosis and following induction therapy to establish if these changes correlated with weight gain or MRD risk.We have shown …
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Zelluläre und molekulare Determinanten der Therapieresistenz bei Kindern mit akuter lymphoblastischer Leukämie
… unter der Therapie (minimale Resterkrankung, MRD) von entscheidender prognostischer Bedeutung. Um Determinanten der Therapieresistenz bei der ALL zu identifizieren, wurden MRD-Zellen mittels genomweiter Genexpressionsanalyse eingehend charakterisiert. Die bioinformatische Auswertung der …
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Pairs-Trading: Umsetzung einer quantitativen Handelsstrategie am deutschen Aktienmarkt zur Prüfung der schwachen Markteffizienz
… in den Jahren 1997 bis 2007 von 118,23 Mrd. Dollar auf 2136,83 Mrd. Dollar steigern. Erst im Jahr 2008 sanken die verwalteten Gelder um 678,93 Mrd. Dollar. Auslöser war die Immobilienkrise in den USA, die weltweit den Kapitalmärkten und auch der Hedge Fonds Branche Kursverluste zufügte. …
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Multilineäre Beteiligung der Leukämogenese in der BCR::ABL1-like Akuten Lymphoblastischen Leukämie
… bilden die Grundlage einer IGH::CRLF2-basierten MRD-Messung mit hoher Konkordanz zur IG/TR-basierten MRD. Zur technisch unabhängigen Bestätigung wurden bruchpunktspezifische MRD-Assays entwickelt und mit der IG/TR-basierten MRD verglichen. Eine unterschiedliche Kinetik zeigte sich nicht. Die …
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Immune Landscape of early liver metastatic lesions in a Novel Immunocompetent Murine Colorectal Cancer Metastasis Model
<p>Colorectal cancer minimal residual disease (MRD) represents a major clinical problem for colorectal cancer patients, with failure rates of surgery and adjuvant chemotherapy between 5% to 40% depending on stage of disease. In our study, we simulated MRD using genetically engineered organoids with …
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Economic Analysis of Farm Household Perceptions and Preferences for Salinity Intrusion Risk Reduction in the Mekong River Delta
… water is intruding into the Mekong River Delta (MRD). Declining flows, as a result of increasing upstream water use, are a primary cause of sea water intrusion. Climate change-induced sea level rise is a secondary cause. Finally, increased water use due to an expansion in the number of farmers …
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Salt-tolerant rice variety adoption in the Mekong River Delta
… role in the economy of the Mekong River Delta (MRD), but rice production is endangered by sea-level rise and the associated increased incidence of salinity intrusion. This study examines the diffusion of salt-tolerant rice varieties (STRVs) in the MRD that were promoted through Consortium for …
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Essays in Health Economics and Applied Econometrics
… with multiple running variables (respectively, MRD and MRK), single-dimensional versions of which have been used for program evaluation in a wide range of settings. In MRD and MRK designs, individuals are assigned different treatments based on whether their values on several observed running …
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Computational Frameworks to Interpret Genetic Abnormalities in Hematologic Malignancies
… (termed "measurable residual disease" (MRD)). I show that NGS-based MRD detection is feasible in different subtypes of AML at various time points. In addition, estimating sequencing error rates helps reduce false positives while increasing true positives, thus maximizing clinical …
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A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
<p>Measurable residual disease (MRD) detection is associated with cancer relapse. Leukemias with rearrangement of the lysine methyltransferase 2 A gene (<em>KMT2Ar</em>) have an adverse prognosis with more than 80 possible fusion partner genes (FPG) identified. With the advent of effective targeted …
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Intentions to engage in a meat-reduced diet: an application of the integrative model of behavioural prediction
… South Africans to engage in a meat-reduced diet (MRD). A two-phase methodology was utilised, by firstly conducting an elicitation study to identify the salient beliefs present in the population, and secondly by conducting a population survey to quantify the cognitive foundation of this behaviour. …
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Improving the Monitoring of Multiple Myeloma Patients Using Blood Based Markers of Disease
… disease, termed minimal residual disease (MRD). Increasingly sensitive techniques are needed to detect this MRD and, as MM is a bone marrow based disease, the majority of techniques focus on bone marrow based assays. However, as bone marrow sampling is invasive, painful and unpleasant for …
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Multi-Modality Plasma-Based Detection of Minimal Residual Disease in Triple-Negative Breast Cancer
… for early detection of minimal residual disease (MRD) on early-stage TNBC patients using next-generation sequencing. For the first part of this study, I focused on detecting circulating tumor DNA (ctDNA) from TNBC patients after neoadjuvant chemotherapy and surgery. First, patient-specific somatic …
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Stromerzeugung in Deutschland unter den Rahmenbedingungen von Klimapolitik und liberalisiertem Strommarkt : Bewertung von Kraftwerksinvestitionen mit Bayes’schen Einflussdiagrammen
… ein Barwertvorteil von insgesamt 8,6 Mrd. €. In ähnlicher Dimension liegen die Barwertvorteile aus der 2009 von der Bundesregierung in Aussicht gestellten Laufzeitverlängerung für Atomkraftwerke. Bei einer achtjährigen Laufzeitverlängerung ergäben sich je nach CO2-Preisniveau …
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Developing an accurate close-range photogrammetric technique for extracting 3D information from spherical panoramic images
… here referred to as the Minimum Ray Distance (MRD), for the fully automated approximate relative orientation of spherical panoramic images. The bundle adjustment algorithm was then applied to refine the orientation parameters of the panoramas; thus enabling accurate 3D point measurement. …
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Support Needs of Agrarian Women To Build Household Livelihood Resilience: A Case Study of the Mekong River Delta
… Soc Trang provinces in the Mekong River Delta (MRD), two regions highly vulnerable to climate change. Data were gathered through in-depth interviews and analyzed by a qualitative analysis process, historical event tracking, and descriptive statistical analyses using R programming. CATWOE …
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Modeling and control of smart structures embedded with magnetorheological devices
… such as the magnetorheological (MR) damper (MRD), pin joint (MRP), and elastomer base isolator (MRE). This study first aims at exploring the solutions to the present problem in system modeling and controller design of MR based systems to effectively damp out unwanted vibrations as well as …
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