Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"MRAP2"”.
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Effect of age and pregnancy on the murine melanocortin system in the female reproductive system
… method (RNAscope®) enabled MC3, MC5 and MRAP2 localisation in the hypothalamus, in the preoptic (rostral and medial) areas and arcuate nucleus. Those areas are known to contain the gonadotropin-releasing hormone (GnRH) neuronal network in the female mouse hypothalamus. The RNAscope® …
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Analyzing the Interactions Between Xenopus tropicalis MC2R, MC5R, and the MRAPs: Modeling the Regulation of Frog Interrenal Cells
… proteins are expressed: MC2R, MC5R, MRAP, and MRAP2. The MRAPs have an opposite effect on the cell surface expression of MC2R and MC5R. In mammals, MRAP aids MC2R but inhibits MC5R cell surface expression. This thesis aims to explore the functional relationship between MC2R, MC5R, MRAP, and …
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Evaluating the Interaction Between the Human Melanocortin-2 Receptor and the Accessory Protein, Mrap1: Chimeric Receptor and Alanine Substitution Studies on Transmembrane Domain 4, Extracellular Loop 2, and Transmembrane Domain 5
… with another MRAP1 protein. Furthermore, MRAP2 creates a heterodimer with the MC2R. Previous studies have shown that the MRAP1 protein contains an activation motif required for activation of MC2R and this activation motif located on the extracellular space side of the plasma membrane of …
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Characterization of the Whale Shark (Rhincodon Typus) Melanocortin-2 Receptor
… basal function, co-expression of wsMRAP1 or wsMRAP2 improved function overall. Analysis of the activation mechanism of the wsMC2R ortholog suggested a hybrid mechanism between the proposed one-step activation mechanism for the elephant shark MC2R ortholog and the proposed two-step activation …