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Showing 1 to 4 of 4 for “"MRAP1"”.
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Evaluating the Interaction Between the Human Melanocortin-2 Receptor and the Accessory Protein, Mrap1: Chimeric Receptor and Alanine Substitution Studies on Transmembrane Domain 4, Extracellular Loop 2, and Transmembrane Domain 5
… the melanocortin receptor accessory protein-1 (MRAP1) for proper trafficking and activation of the receptor by the melanocortin hormone, ACTH. MRAP1 is a single transmembrane-spanning domain protein that creates a homodimer with another MRAP1 protein. Furthermore, MRAP2 creates a heterodimer …
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Analyzing the Interaction Between Melanocortin 5 Receptor, Melanocortin Receptor Accessory Protein 1, and Melanocortin 2 Receptor in Rainbow Trout
… trout MC5 receptor (rtMC5R) with zebrafish MRAP1 (zfMRAP1) and rainbow trout MC2 receptor (rtMC2R), as well as how the effect of such relationships may play a significant role in Hypothalamic-Pituitary-Adrenal/Interrenal axis activation. This research demonstrated that rtMC5R can be …
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Effect of age and pregnancy on the murine melanocortin system in the female reproductive system
… The melanocortin receptor accessory proteins (MRAP1 and 2) influence MC receptor transport and signalling. The MCs are activated by proopiomelanocortin (POMC) derivatives: alpha-, beta-, and gamma-melanocyte stimulating hormones and adrenocorticotrophic hormone; while agouti signalling peptide …
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Characterization of the Whale Shark (Rhincodon Typus) Melanocortin-2 Receptor
… that it is dependent on its accessory protein, MRAP1, for trafficking and activation, and is selective for activation by ACTH alone. Previous studies on the MC2R orthologs of select cartilaginous fish, the elephant shark (<em>Callorhinchus milii</em>) and the red stingray (<em>Dasyatis …