Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"MPTP model"”.
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Exploring the Role of PANNEXIN1A in an Acute Experimental Model of Parkinson's Disease
… Pannexin1 ortholog Pannexin1a in a zebrafish model of MPTP-induced early stages of Parkinson’s disease at molecular, systems, and behavioral levels. The short-term treatment of wild-type TL and gene-edited Panx1a-KO larvae caused metabolic stress, regulated inflammatory pathways, and reduced …
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α-Synuclein phosphorylation and related kinases in Parkinson’s disease
… kinases in the progression of PD and in animal models of PD, and to determine whether Tenuigenin (TEN), a Chinese medicinal herb, can prevent α-synuclein-induced toxicity in a cell model. The levels of non-phosphorylated α-synuclein decreased over the course of PD, becoming increasingly …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… agonists are neuroprotective in experimental PD models in rodents and primates. however safety concerns have been raised about PPARγ agonists thiazolidinediones (TZD) currently available, prompting for the development of non-TZD compounds. Aim of this study was to characterize a novel PPARγ …
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Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
… im 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) Maus Modell der Parkinson Erkrankung zeigen. Die unilaterale, striatale Vektorapplikation resultierte in der Bereitstellung von biofunktionalem GDNF im Striatum und der SN beider Hirnhemisphären, wenn GDNF in Neuonen exprimiert worden ist; …