Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"MPTP"”.
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Molecular basis of MPTP-induced Parkinson's disease
… of 1-methyl-4-pheny]-1,2,3,6-tetrahydropyridine (MPTP) has resulted in irreversible symptoms of Parkinson's disease in several young drug abusers. It was found that this neurotoxicant selectively destroys neuronal cells in the substantia nigra of humans and other primates. Although the mechanism …
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Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
… im 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) Maus Modell der Parkinson Erkrankung zeigen. Die unilaterale, striatale Vektorapplikation resultierte in der Bereitstellung von biofunktionalem GDNF im Striatum und der SN beider Hirnhemisphären, wenn GDNF in Neuonen exprimiert worden ist; …
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Studies on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and analogs
… I-methyl-4-phenyl-l ,2,3,6-tetrahydropyridine (MPTP) is a potent and specific neurotoxin that causes a parkinsonian like syndrome in humans and subhuman primates. Research has revealed that MPTP is bioactivated in a reaction catalyzed by flavin containing monoamine oxidase B (MAO B) to yield the …
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NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
The main, underlying cause of neurodegenerative disease is the progressive loss of neuronal structure or function, whereby central and/or peripheral nervous system circuitry is severely and irreversibly damaged, resulting in the manifestation of clinical symptoms and signs. Neurodegenerative …
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Synthetic and Natural Environmental Compounds as Potential Facilitators of Mptp-Induced Parkinsonism
… to the discovery of the nigrostriatal neurotoxin MPTP. MPTP can induce dopamine specific degeneration within the basal ganglia often resulting in motor deficits similar to PD. MPTP used in the C57BL/6 mouse is a widely used animal model of PD. The pyrethroid permethrin (PM), and the …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease. MPTP induced degeneration of nigrostriatal DA neurons and glial activation as visualized by tyrosine hydroxylase, macrophage antigen complex-1, and/or glial fibrillary acidic protein immunoreactivity. …
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Synthesis and biological evaluation of novel MPTP analogs as potential monoamine oxidase B inhibitors
… 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and close structural analogs are the only known cyclic tertiary amines with good monoamine oxidase substrate properties. In addition to its substrate properties, MPTP is a weak mechanism-based inactivator of monoamine oxidase-B (MAO-B). In an …
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Effects of MPTP, MPP(+) and Adreno-Medullin on Dopamine Metabolism in the Rat Corpus Striatum
… of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a contaminant on illicit narcotic drugs, causes parkinsonism symptoms in drug addicts. Also, systemic injections of very low doses of MPTP in non-human primates produces selective destruction of the nigrostriatal dopamine neuron and severe …
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Studies on the monoamine oxidase substrate/inactivator properties of piperidine analogs of the neurotoxin MPTP
The unexpected monoamine oxidase (MAO) substrate properties of 1-cyclopropyl-4-substituted-1 ,2,3,6-tetrahydropyridines have been interpreted in terms of partitioning of these tertiary cyclic allylamines between substrate turnover and ring opening inactivation processes. To evaluate further this …
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) in an in vitro model SH-SYSY human neuroblastoma cells were explored using cytotoxic effects, neurochemical changes and pathological injury as endpoints. The results suggested that: MPTP entered the SH-SYS5Y human neuroblastoma cells through a …
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Einfluss des GDNF-Rezeptors Ret auf die Erholung des nigrostriatalen Systems im MPTP-Mausmodell der Parkinsonerkrankung
… von 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridin (MPTP) ist das beste charakterisierte Tiermodell des IPS. Daher wurden Ret-defiziente Mäuse und Kontrollen an 5 aufeinanderfolgenden Tagen gewichtsadaptiert mit 30 mg/kg KG MPTP oder 0,9% Natriumchlorid (NaCl) injiziert. Um den langfristigen Einfluss …
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Effects of Central and Peripheral Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (Mptp) in the Rat and Mouse
MPTP has been observed to cause irreversible symptoms of parkinsonism associated with selective degeneration of the substantia nigral dopamine neurons in the midbrain of man and monkeys. Although rodents are less sensitive to the neurotoxic action of MPTP, it has been found that central …
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The Role of Bax and Bak in Necrotic Cell Death
… the mitochondrial permeability transition pore (MPTP). The MPTP is thought to span the intermembrane space of the mitochondria and to consist of both an inner and outer component on the mitochondrial membranes. The molecular identity of these two membrane components of the MPTP remains …
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Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction
… 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP), a complex I inhibitor, produces a Parkinsonian state in mammals. The aims of the present study were to determine the effects of MPTP on the mitochondrial proteome in a cellular model using mouse N2a neuroblastoma cells and to identify novel …
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Synthesis and mechanistic studies on the monoamine oxidase (MAO) catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines
… 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium (MPDP+) subsequently pyridinium (MPP+) metabolites. As part of our ongoing studies to characterize the …
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Investigation into the effects and mechanisms of rapamycin treatment in two mouse models of Complex I-deficient neurological pathology
… (NDUFS4 KO) mouse for Leigh Syndrome and the MPTP mouse model for Parkinson's disease. In these models, mitochondrial electron transport chain complex I activity is reduced but results in distinct patterns of neuronal pathology. Our major objectives were (1) to identify previously unreported …
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Serotonergic and dopaminergic systems as targets for exogenous neurotoxins causing a parkinsonian syndrome
This thesis explored the mechanism of action of MPTP and its toxic metabolite, MPP⁺, and compared it to the mechanism of action of haloperidol metabolites, some of which are found in schizophrenic patients. Experiments assessed the effects of these compounds on several aspects of amine uptake in …
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Synthetic and metabolic studies on 1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine, a neurotoxic analog of the Parkinsonian inducing agent MPTP
… analog of the parkinsonian inducing agent MPTP. TMMP and its putative metabolites 1-methyl-4-(1-methylpyrrol-2-yl)-2,3-dihydropyridinium (MMDP+) and 1-methyl-4-(1-methylpyrrol-2-yl)pyridinium (MMP+) were synthesized and fully characterized. Substrate/inactivation properties of TMMP and its …
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Exploring the Role of PANNEXIN1A in an Acute Experimental Model of Parkinson's Disease
… ortholog Pannexin1a in a zebrafish model of MPTP-induced early stages of Parkinson’s disease at molecular, systems, and behavioral levels. The short-term treatment of wild-type TL and gene-edited Panx1a-KO larvae caused metabolic stress, regulated inflammatory pathways, and reduced ATP …
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Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice
… 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin known to induce PD in humans, in motor, limbic and cortical areas, and consequently affects cognitive performance. Mice received MDMA (10 mg/kg, twice a day/a week) for 9 weeks, followed by MPTP (20 mg/kg × 4 administrations), …
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