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Showing 1 to 20 of 20 for “"MPNs"”.
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CLINICAL AND LABORATORY CHARACTERISATION OF ACQUIRED VON WILLEBRAND SYNDROME
… (LPDs) and myeloproliferative neoplasms (MPNs), cardiovascular, and autoimmune conditions. The underlying biological processes differ across clinical contexts and remain incompletely defined, complicating both diagnosis and management. Aim: To characterize AVWS based on clinical …
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Interfacial Nitrone 1,3-Dipolar Cycloadditions for Modification of Monolayer Protected Gold Nanoparticles
… of monolayer protected gold nanoparticles (MPNs) is critical for the understanding and development in their potential application. While various methods for the incorporation of functionality onto MPNs are available, many require tedious synthesis dependant solely upon its application. A …
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Detection of the calreticulin type 1 and type 2 mutations in a group of myeloproliferative neoplasm patients using molecular methods
… of disorders, now classified as the classic MPNs, include chronic myeloid leukaemia (CML), as well as the Philadelphia (Ph) chromosome-negative MPNs: polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) or myelofibrosis (MF). In 2013, somatic mutations at …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… JAK2 V617F mutant myeloproliferative neoplasms (MPNs) as a model. This study utilises single-cell gene expression and functional assays to identify a subset of JAK2 V617F mutant HSCs that display defective self-renewal. This defect is rescued by crossing JAK2 V617F mice with mice lacking TET2, …
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Mechanistic investigations of enzymes in phosphonate metabolism
… homology to HEPD, methylphosphonate synthase (MPnS), which likewise breaks the carbon-carbon bond of 2-HEP. These results strongly suggested the possibility of a consensus mechanism between HEPD and MPnS. This hypothesis was further evaluated through a combination of substrate analog …
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New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
… myelofibrosis, two myeloproliferative neoplasms (MPNs) characterised by megakaryocyte hyperplasia. Despite the large body of research built around CALR mutations, many aspects of the oncogenic mechanisms of CALR in MPNs remain unanswered. This investigation aims to investigate whether CALR …
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Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms
<p>Myeloproliferative neoplasms (MPNs) are a hematopoietic disease characterized by hyperproliferation of cells of the myeloid lineage for which current therapeutic options are limited. Discovered in 2005, the JAK2V617F mutation is the most common driver mutation in BCR-ABL negative MPNs, resulting …
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Understanding the role of extrinsic regulators in normal and malignant haematopoiesis
… known as the myeloproliferative neoplasms (MPNs). This work identified key regulators of the preleukaemic state, including two potential biomarkers of disease evolution, and additional molecules that associated with advanced disease (Chapter 4). This correlation of cytokine levels with …
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Mikrobieller Metabolismus von 2,4-Dichlorphenol in der Drilosphäre und Einfluss auf die N2O-Bildung : Verknüpfung von Prozessen mit Populationen
… weniger effizienten Abbau. Erfasste Keimzahlen (MPNs) anaerober 2,4-DCP Verwerter in feldfrischem Boden waren signifikant niedriger als die korrespondierender aerober Abbauer. Bodensäulenversuche mit feldfrischem Ackerboden zeigten eine kontinuierliche Abnahme in situ relevanter 2,4-DCP …
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Diverse enzyme reactions in phosphonate natural product biosynthesis
… these environments. The oxygenase MPn synthase (MPnS) produces MPn from 2-hydroxyethylphosphonate (2-HEP), a substrate also acted on by 2-HEP dioxygenase (HEPD) to make hydroxymethylphosphonate (HMP). Both enzymes are proposed to share a common mechanism up until the final intermediate consisting …
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Study Of Covalent And Non-Covalent Interactions In Ternary Systems Involving: Metal/DNA-RNA/Protein, Where Metal = Platinum(II), Palladium(II)
… Platinum-nucleobase complexes (MPNs) are synthesized via substitution of a chloride ligand by a nucleobase in platinum complexes with trans geometry. MPNs are particularly interesting for the study of ternary systems since they mimic the first step in the formation of a …
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Platinum Complexes and Zinc Finger Proteins: From Target Recognition to Fixation
… trans platinum-nucleobase complexes (MPNs) serve as a model for the binding of transplatin to DNA. This provides an interesting opportunity to study their reactions with S-containing proteins, such as HIV1 NCp7. MPNs have been shown to bind to the C-terminal ZF of HIV1 NCp7, resulting …
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The molecular pathogenesis of myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cell<br/>malignancies characterised by proliferation of one or more cells of the myeloid lineage. The molecular<br/>investigation of MPN was revolutionized in 2005 by the finding that approximately 95% of cases …
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Degradation of tertiary butyl alcohol by a Pseudomonas sp. isolated from groundwater
… have a history of petroleum contamination, had MPNs of < 2 TBA degrading organisms/g (dry wt) indicating a natural enrichment process at the refinery site. The Q<sub>O2</sub> of <i>Pseudomonas</i> sp. was 4.2 ml O₂/mg dry wt/h when TBA was the substrate. The optimum pH for growth was 7.0. The …
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Inferring Clonal Dynamics in Blood using Single-Cell Measurements
… related cells in myeloproliferative neoplasms (MPNs) favor particular blood cell fates. Myeloproliferative neoplasms are clonal disorders driven most frequently by the JAK2-V617F mutation, which arises in a single hematopoietic stem cell (HSC) and ultimately dominates the normal process of blood …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
… in myeloproliferative neoplasms (MPNs). In summary, these results suggest that HSC niche remodelling and a functional switch of sympathetic activity (β2-AR overriding β3-AR) contribute to myeloid expansion during normal ageing. Certain ageing features in HGPS and aged-related …
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Evolution of the genome in myeloproliferative neoplasms and the methylome in blood
… evolution in myeloproliferative neoplasms (MPNs) and identify changes in the methylome of blood with age and in the context of driver mutations. In the first study, serial sequencing of bulk samples from 30 patients with MPN coupled with clinical data show that clonal evolution is associated …
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Identification of Novel Drivers of Haematopoietic Stem Cell Fate Using Low Cell Number Proteomics and Single Cell Profiling
… disorders, such as myeloproliferative neoplasms (MPNs), and ultimately to their transformation to acute myeloid leukaemia. Therefore, we urgently require a complete characterisation of the underlying molecular pathways of HSC self-renewal in order to provide crucial insights into disease …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) commonly result from the acquisition of somatic mutations affecting the Janus kinase 2 (JAK2) (such as JAK2<sup>V617F</sup>) or the multi-functional protein CALR (such as CALR<sup>Ins5</sup> and CALR<sup>Del52</sup>), causing the constitutive activation of signal …
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Determinants of clinical phenotype in myeloproliferative neoplasms
Background: Myeloproliferative neoplasms, (MPNs) such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of patients with myeloproliferative neoplasms offers the potential for personalized …