Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"MPLA"”.
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Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
Monophosphoryl lipid A (MPLA) is a Toll-like receptor 4 agonist that has been approved for use as a vaccine adjuvant in humans. In these studies, we evaluated the effect of MPLA treatment on the innate immune response to systemic infection in mice with emphasis on bacterial clearance, leukocyte …
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Discourse, Practices and Historical Representations in Two Guerrilla Groups: the Eln and the Mpla, Colombia-Angola, 1956-1986
… Army of Liberation, 1963) and the MPLA (Movimento Popular de Libertação de Angola/Popular Movement for the Liberation of Angola, 1956). The goal is to provide an interpretation of the rise, transformations and uses of specific forms of historical representations. In the form of …
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New Carbohydrate-Based Anti-Cancer And Anti-Bacterial Vaccines
… carriers, such as monophosphoryl lipid A (MPLA), to construct full-synthetic carbohydrate-based vaccines that have well-defined structures and improved immunological properties. The main aims of this dissertation are to study</p> <p>and evaluate these semi- and full-synthetic …
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Immunoprotective effects of lipopolysaccharide detoxification by a novel microbial-derived alkaline phosphatase
… product, monophosphoryl lipid A (MPLA). Based on IAP’s ability to reduce the inflammatory effects of LPS in the GIT and the difficulty in creating a viable commercial product from a mammalian-derived enzyme; a microbe was engineered to produce an alkaline phosphatase (MAP). …
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A built-in self-test PLA generator
… circuit. Implementation of BPG was based on MPLA, a PLA generator. Tiles necessary for BIST PLAs were created and added to the existing PLA tiles. The source code of MPLA was modified in order to place proper tiles and generate layouts of BIST PLAs. A circuit was extracted from a BIST PLA …
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Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction
… the co-delivery of monophosphoryl lipid A (MPLA) and Resiquimod (R848) achieved a considerably higher antibody titer and brain nicotine reduction than only using MPLA or R848 alone as adjuvants. Collectively, the findings from this study may lead to a better understanding of the impact of …
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Effective client management: maximizing the influence of external sponsors over affiliated armed groups
… its offshoots, and of Cuba's sponsorship of the MPLA in Angola. The research supports the delineation of five critical factors of effective client management: sponsor competition, client competition, sponsor oversight, client organizational enforcement, and client dependence. Additionally, the …
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"The father of the revolution": history, memory and the FNLA veterans of Pomfret
… Portuguese colonialism, and later against the MPLA Soviet"puppet" regime. For the ex-FNLA fighters, the FNLA stood for progress, inclusivity, and justice, to the extent that many of these former fighters have proclaimed their continued loyalty to the FNLA to this day. By making use of concepts …
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Soviet Strategy Toward African National Liberation Movements
… the Movimento Popular de Libertacao de Angola (MPLA), and (c) Soviet strategy toward the Zimbabawe African People's Union. The author concludes that in each of the above cases Soviet strategy generally conformed to the model strategy during the 1970s. However, since 1980 Soviet strategy has …
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Layer-by-Layer Nanoparticles for Cytokine Delivery
… (ISCOMs) co-loaded with monophosphoryl-lipid-A (MPLA) via a scalable approach for clinical-scale manufacturing of the adjuvant termed Saponin MPLA NanoParticles (SMNP). Moreover, we discover that this approach allows for precise control over liposome size from 50 nm to 1 µm with minimal …
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Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses
… agonists (TLRa), monophosphoryl lipid A (MPLA) and Polyinosinic:polycytidylic acid (poly (I:C) or pIC) added to ICMVs as adjuvants. Pulmonary administration of ICMV with both adjuvants was found to give the most potent CD8 T cell response in both systemic and mucosal compartments. We …
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Molecular design of nanoparticle-based delivery vehicles for pneumonic plague
… While the combination of a commercial adjuvant (MPLA) or unloaded 50:50 nanoparticles with soluble antigen was able to convey some protection at 6 weeks post-vaccination, only a combination of soluble antigen with antigen-loaded 50:50 CPTEG:CPH nanoparticles was able to convey 100% protection at …