Global ETD Search
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Showing 1 to 4 of 4 for “"MPGES-1"”.
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Development of Novel, Brain Permeable, mPGES-1 Inhibitors for Inflammatory Conditions
… COX. Microsomal prostaglandin E synthase-1 (mPGES-1) is the major producer of PGE2 during inflammation and therefore represents a more specific therapeutic target to combat inflammation. Although a promising target, mPGES-1 inhibitors have been difficult to develop due to the interspecies …
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Binding and Signaling Differences between Prostaglandin E1 and E2 Mediated by Prostaglandin E Subtype Receptors
… a newly engineered hybrid enzyme (COX-2-10aa-mPGES-1) linking COX-2 and mPGES-1 together thus adopting the full biological activity of COX-2 and mPGES-1 in directly converting AA to PGE2. This enzyme was genetically introduced into HEK293 cells. These cells expressing the COX-2-10aa-mPGES-1 …
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Mechanisms of inflammation resolution in a murine model of Lyme arthritis
… resolve more efficiently in PGE2-deficient mPGES-1-/- mice due to enhanced bacterial control in the joint. Further, disruption of early inflammation in mPGES-1-/- mice by PGE2 addback worsened arthritis outcomes. We also designed an in vivo staining method to characterize neutrophil reverse …
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Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
… localization predominantly in membrane fraction. mPGES-1: is almost not expressed in resting cells; mPGES-1 expression is highly increased by LPS, dexamethasone suppresses the LPS effect, localization in membrane fraction. mPGES-2: is expressed in resting Kupffer cells; mPGES-2 expression is …