Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MP-12"”.
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Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
… control of RVF outbreaks via vaccination is important for both endemic and non-endemic countries. In some countries in Africa, inactivated and/or live-attenuated vaccines have been available for vaccinations of susceptible ruminants. In the U.S., a live-attenuated MP-12 vaccine strain was …
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Host response to Rift Valley fever virus infection
… date, there is little detailed data directly comparing the host response to infection with RVFV and correlation with viral pathogenesis. My goal was to be able to discern the host response to infection and to correlate the response with development of RVFV-induced pathogenesis. My efforts have …
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
… in response to the virus. DCs infected with rMP12-C13type virus, encoding a non-functional NSs protein, were able to initiate increased levels of maturation marker presentation of CD40, CD86 and CD83 and were also able to induce higher levels of proinflammatory molecules while rMP-12 and …
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The Impact of the Non-Structural Small Segment Gene on Host Immune Responses Against Rift Valley Fever Virus
… conditions. The severe health and economic impacts RVFV exerts on endemic regions demands the urgent development of effective preventive and therapeutic interventions. To address the need for livestock and human vaccines, several live attenuated vaccine platforms have been proposed. Primarily …
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Reverse genetics system and fucntion of NSM protein of Rift Valley fever virus (family Bunyaviridae, genus phlebovirus)
… system to rescue infectious clones of RVFV MP-12 strain entirely from cDNA, the first for any phleboviruses. Using this system, RVFV carrying substitution mutations of the M gene preglycoprotein region (pre-Gn region), one lacking NSm protein expression, one lacking 78-kDa protein …
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OROPOUCHE VIRUS DISRUPTION OF HOST CELL FUNCTIONS: PYROPTOSIS INDUCTION AND TRANSCRIPTIONAL SUPPRESSION
… While typically self-limiting, severe complications such as aseptic meningoencephalitis, miscarriage, and neonatal malformations can occur. This dissertation contributes to the better understanding of OROV and its host-pathogen interactions by exploring its effects in macrophages as well …