Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"MOUSE MAMMARY GLAND"”.
-
Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
… breast remain relatively uncharacterised. The mammary epithelium and blood vasculature undergo dynamic remodelling events in response to hormonal signals and functional demands during postnatal mouse mammary gland morphogenesis (Djonov et al., 2001; Matsumoto et al., 1992; Richert et al., 2000; …
-
CHARACTERIZATION OF THE GLUCOCORTICOID RECEPTOR IN MOUSE MAMMARY GLAND DURING PREGNANCY AND LACTATION.
… OF THE GLUCOCORTICOID RECEPTOR IN MOUSE MAMMARY GLAND DURING PREGNANCY AND LACTATION.
-
Gene Set Analysis of Post-Lactational Mammary Gland Involution Gene Signatures In Inflammatory and Triple Negative Breast Cancer
… each cycle of pregnancy and lactation, the mammary gland undergoes dramatic changes. Clarkson et al. (2004) and Stein et al. (2004) conducted a detailed analysis of these changes in the mouse mammary gland. Their results showed that tissue remodeling during post-lactational involution period …
-
Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
… Utilizing lentivirally transduced stable mouse mammary gland epithelial (NMuMG) and triple-negative human breast epithelial (MDA-MB-231) cells expressing GJA1-20k, or Lac Z as control, we tested effects on TGF-β-induced EMT induction and metastatic trait induction. Boyden chambers, …
-
ZFAS1: a long non-coding RNA with novel implications for ribosome function
… is ZFAS1 that is differentially expressed in mouse mammary gland development and breast cancer. The primary objective of this thesis was to understand how ZFAS1 may contribute to regulation of cellular processes using breast cancer as a model. We have found ZFAS1 expressed in high abundance in …
-
The Role of Insulin-like Growth Factor-I and IGF-binding Proteins in Mammary Gland Development
Development of the mammary gland is likely mediated by locally produced growth factors acting in concert with circulating mitogens. To investigate the importance of mammary synthesis of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBP), the initial objective was to evaluate the …
-
Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
In the mammary gland, genetic circuits controlled by the hormones, estrogen, progesterone and prolactin (PRL), act in concert with pathways regulated by the epidermal growth factor (EGF) family to control the growth and morphogenesis of this tissue during puberty, pregnancy and lactation. However, …
-
Trim24 As An Oncogene In The Mammary Gland
… to assess. My project takes advantage of a new mouse model to understand the role of a proto-oncogenic, transcriptional co-regulator, TRIM24, in mammary gland development and disease.</p> <p>We previously reported an unknown binding partner and negative regulator of p53, Tripartite Motif protein …
-
On Different Uses of Abstraction in Models of Developmental Systems
… branching morphogenesis in the developing mouse mammary gland. A brief reprieve from the theoretical concerns of the preceding chapters comes with Chapter 4. A stand-alone analysis of gene expression data from the Drosophila embryo, this chapter establishes the presence of artefacts which …
-
THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
… observed during branching morphogenesis in the mammary gland. For example, a microarray analysis of gene expression in terminal end buds identified elevated levels of EMT regulators, Snail and Twist, in the mammary gland. Additionally, a transgenic mouse model overexpressing a regulator of EMT, …