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Showing 1 to 20 of 22 for “"MOG"”.
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… to the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in MS, is heterogeneous and that MOG exhibits extensive immunological cross-reactivity with the bovine milk protein butyrophilin (BTN), an ubiquitous dietary antigen. In a subset of MS patients this …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
This study investigated the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
… the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in multiple sclerosis, to induce tolerance and protect against experimental autoimmune encephalomyelitis (EAE) was assessed. Unexpectedly, mice vaccinated with MOG-DNA develop an exacerbated form of EAE when …
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Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis
… during myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmuneencephalomyelitis (EAE) identified a public TCRβ chain, TCRβ1, which was highly shared among individual mice and preferentially deployed during EAE. Retrogenic expression of TCRβ1 resulted in spontaneous …
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Expressionsmuster Gewebe-spezifischer Antigene in Thymus-Epithelzellen der Maus
… Proteinexpression wurde für Insulin, P1A, PLP, MOG, Somatostatin und S100beta gefunden. Diese Antigene (bis auf MOG) wurden in medullären Epithelzellen des Thymus exprimiert, die Frequenz der exprimierenden Zellen betrug 100 PLP und S100beta wurden ebenfalls in kortikalen Thymus-Epithelzellen …
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Systematische Charakterisierung und Untersuchung der Inzidenz von Myelitis-assoziierten Autoantikörpern bei akuten Myelitiden
… beschreibt die Myelitis als Krankheitsbild in demographischen, klinischen, bildmorphologischen und laborchemischen Parametern und zeigt eine Zuordnung zu verschiedenen Ätiologien auf. Die soll als systematische Übersichtsarbeit dienen. Zudem Untersuchung der Prävalenz von …
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Modelling Effective Connectivity in Functional Magnetic Resonance Imaging Data by State Space Models
… (lingual gyrus, LG, and middle occipital gyrus, MOG, in this experiment). There is also strong evidence indicating heterogeneity in the subjects' connectivity between LG and MFG. Moreover, the strength of the connectivity between LG and MFG, and between MOG and MFG show decreasing trend during …
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… myelin oligodendrocyte glycoprotein peptide (MOG₃₅₋₅₅)-specific CD8 T-cells do not mediate EAE, but in fact are capable of suppressing both de novo and established clinical disease. Corroborating these data, CD8-/- C57BL/6 mice are now shown to exhibit a more severe EAE. However, the …
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Neural markers of antisocial behaviour in offenders and their relationship with risk-factors of offending
… the left IFG and increased activity in the left MOG compared to non-offenders. Thus, some dysfunctions spanned across both resting-state and task-based metrics (i.e., within left IFG and left MOG), suggesting stable abnormalities between offenders and non-offenders, while rest-related …
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Amelioration of the chronic relapsing experimental allergic encephalomyelitis (CR-EAE) using thymoquinone
… weeks of age were placed into 3 groups of 10 and MOG was used subcutaneously (s.c) to induce EAE. Group A, the control group. Group B, received MOG (s.c) and TQ intraperiotoneally (i.p) from day 1 till day 50. Group C, received MOG (s.c) and TQ (i.p) was given on the appearance of first sign and …
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Charakterisierung der subzellulären Lokalisation von Myelinproteinen in der Shiverer-Maus.
… MAG (Myelin assoziiertes Glykoprotein) und MOG (Myelin Oligodendrozyten Glykoprotein) in deutlichem Ausmaß vesikulär perinukleär lokalisiert sind, während diese Verteilung im adulten Wildtyp kaum zu finden ist. Das Phänomen findet sich im Wildtyp allerdings in einem frühen, zeitlich …
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Speeding up Adaboost object detection with motion segmentation and Haar feature acceleration
… preprocessing step. We use Mixture of Gaussians (MoG) proposed by Staffer et. al. for object segmentation. One key advantage with using segmentation to extract image regions of interest is that it reduces the number of search windows sent to detection task, thereby reducing the computational …
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Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
… mit Myelin-Oligodendrozyten Glykoprotein (MOG), in braunen Norweger-(BN)-Ratten in 90 % der Fälle zu einer Optikusneuritis führt. Dieser Sehnervenbefall ist gekennzeichnet durch entzündliche Infiltration, Demyelinisierung und axonale Degeneration. Die genauen Mechanismen der …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… with the myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide. MOG-reactive inflammatory CD4+ T cells infiltrate the CNS and, in concert with other mononuclear cells, cause inflammation and progressive paralysis. The focus of the first study was to evaluate the immunoregulatory role of …
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The Role of Therapy-Induced CD8+ T Cells in a Mouse Model of Multiple Sclerosis
… decreased myelin oligodendrocyte glycoprotein (MOG)-specific CD4+ T cell responses. In conclusion, our studies provide strong evidence that the in vivo induction of immune modulatory CD8+ T cells is an essential step in mediating therapeutic protection during autoimmune demyelination.
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Partial Molecular and Biochemical Characterization of a Sandhoff Mouse Model
… were related to myelination: Ugt8a, Fa2h, and Mog. They were assessed at 3 time points: 5 weeks, 10 weeks, and 16 weeks. Secondly, this study profiled metabolite changes in the serum and urine of SD mice, at the same time points, through the use of mass spectrometry. Gene expression analysis …
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Der Einfluß von Virusinfektion und Impfung auf autoreaktive T-Lymphozyten bei der Multiplen Sklerose
… die zwei untersuchten Myelin-Antigene MBP und MOG. Im Gegensatz dazu konnten mit dem IFNg-ELISPOT-Assay bei einigen gesunden Spendern und MS-Patienten nach natürlichen Atemwegsinfektionen eine erhöhte Frequenz autoreaktiver MBP-spezifischer T-Lymphozyten beobachtet werden. Im zweiten Teil …
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Intestinal delivery of heterologous peptides with lactobacilli
… (PLP) and myelin oligodendrocyte glycoprotein (MOG). Two series of vectors has been constructed which direct the expression of these antigens either anchored to the cell wall or secreted into the environment. However, we only confirmed that PLP epitopes expressed from cell lysate of recombinant …
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Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis
… Ex vivo analysis showed that treatment of MOG-specific T cells from EAE affected mice with the mTOR inhibitor, Rapamycin, and the dual PI3K/mTOR inhibitor, BEZ-235, was able to significantly reduce antigen-specific proliferation. In addition, we show that Rapamycin treatment of murine T …
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Ex vivo Charakterisierung von humanen Autoantigen-spezifischen CD4+ T-Zellen mit Fokus auf Multiple Sklerose
… (MBP), das Myelin-Oligodendrozyten Protein (MOG) und das Proteolipidprotein (PLP) aus MS-Patienten und passenden gesunden Kontrollen gelegt. CD4+ T-Zellen mit Spezifitäten für Multiple Sklerose-, Diabetes mellitus Typ I- und Myasthenia gravis-assoziierte Antigene waren in allen gesunden …
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