Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"MODY3"”.
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Modeling Monogenic Diabetes Mody3 Using Human Pluripotent Stem Cells
… Maturity Onset Diabetes of the Young 3 (MODY3) caused by heterozygous mutations in the transcription factor HNF1A. In this thesis research, we found that the lack of HNF1A does not impair the generation of beta-like cells; Wild-type (WT) and mutant cell lines presented similar …
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Energy Homeostasis During Fasting and Fed States: Foxa2 Regulates Hepatic Amino Acid Uptake
<p>In MODY3 patients, as well in the experimental mouse model, the Tcf1 -/- mouse, there is a defect in arginine-induced insulin secretion. In this thesis, we examined the role of arginine transporters in the insulin secreting cells in arginine-induced insulin secretion. We first characterized …