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Showing 1 to 3 of 3 for “"MODULAR SCAFFOLDS"”.

  1. Designed bifunctional proteins for induced degradation of androgen receptor in prostate cancer

    … proteins (CTPRs) were deployed as artificial modular scaffolds, onto which AR- and E3 ligase-binding moieties were grafted to induce AR ubiquitination and degradation. As the degraders bind AR through protein-protein interactions, we can effectively target sites distant from the ligand-binding …

    cambridge Repository record for Designed bifunctional proteins for induced degradation of androgen receptor in prostate cancer (opens in a new tab)

  2. A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules

    … with the currently available conventional scaffolds and fabrication techniques still remains a challenge. To reproduce the full functionality there is a need to engineer tissue constructs that mimic the innate architecture and complexity of natural tissues. The limited ability to …

    wayne-thes Repository record for A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules (opens in a new tab)