Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"MNV"”.
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Modulators of Innate Gut Immunity to Enteric Viral Infections: Murine Norovirus (MNV) as a Model
… age. In this thesis, using the Murine Norovirus (MNV) oral infection model, I aimed to characterize intestinal mucosal antiviral-responses with specific focus on the role of IELs, the impact of aging and the influence of certain micronutrients whose effects are mediated through the Aryl …
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Factors That Influence Murine Norovirus Stability and Tropism
… two independent projects. Murine norovirus (MNV) is a model system used to study human noroviruses due to its robust replication in cell culture and mouse model. I first investigated the interactions between MNV and bacteria in vitro by determining what bacteria and bacterial components could …
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Norovirus Translation and Replication
… with cultivating HuNoV, murine norovirus (MNV) was used as a surrogate system to understand the role of eIF4E phosphorylation in norovirus pathogenesis, and VP1-RdRp interaction in regulating viral genome replication. MNV infection results in the phosphorylation of the translation …
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Investigating the Effects of Glycochenodeoxycholic Acid on Mutant Murine Norovirus P-Domain Structure and Antibody Interactions
… we investigated a novel murine norovirus (MNV) mutant and the effects of native gastrointestinal cofactor glycochenodeoxycholic acid (GCDCA) on its P-domain dynamics and antibody interactions. Cryo-electron microscopy and image reconstruction were used for structural determination of the …
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Incorporation of selected plant extracts into edible chitosan films and the effect on the antiviral, antibacterial and mechanical properties of the material
… significantly (p<0.05) reduced murine norovirus (MNV-1) plaques by 1.69, 2.47, and 3.26 log after 3 h exposure, respectively. Similarly, the FFS containing 2.5 and 5.0% GTE reduced MNV-1 counts by 2.45 and 3.97 log10 PFU/ml, respectively after 3 h exposure. Additionally, the edible films enriched …
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Characterisation of the Mechanism of Norovirus VPg-Nucleotidylylation
… viral polymerase (NS7). Using murine norovirus (MNV) as the primary model, this project sought to better understand this key stage of the norovirus life cycle, providing insight into a previously ill-characterised crucial stage of the viral life cycle and may help to identify key points which …
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Identification of Viral Determinants of Murine Norovirus Pathogenesis
… models to study. In contrast, murine norovirus: MNV) has been a critical surrogate for the study of human noroviruses as it is the only member of this genus that establishes infection in a small animal model, can be grown in cell culture, and has a reverse genetics system. Noroviruses are divided …
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A study of norovirus: molecular epidemiology, pathogenesis and antiviral development
… Another aim of this thesis was to understand how MNV infection avoids the host innate immune response using murine NoV (MNV) as a surrogate model of human NoV. Work in this thesis provides evidence that NoV employs strategies to regulate type-I IFN signalling pathways by inhibiting IRF3 activation …
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The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… two models of viral infection, murine norovirus: MNV) and encephalomyocarditis virus: EMCV), we demonstrate that both MDA5 and TLR3 limit viral replication. Neither MDA5-/- nor TLR3-/- animals controlled MNV and EMCV infection as well as wild type: WT) controls, but DKO mice were more susceptible …
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Mn(salen)- und Fe(porph)-katalysierte enantioselektive Epoxidierungen
… Abspaltung der Fluchtgruppe zum etablierten MnV(oxo)-Komplex reagieren (Weg 1) oder direkt das Olefin epoxidieren (Weg 2). Während die Sauerstoffübertragung durch die Oxo-Spezies stufenweise über ein Radikalintermediat verläuft und damit zu einer Mischung aus cis- und trans-Epoxid führt, …
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Germline mutation in rare disease
… pathogenic impact of multi-nucleotide variants (MNVs). These are variants that fall within 20 base pairs of each other and are frequently misannotated in variant-calling pipelines. Using data from the Deciphering Developmental Disorders (DDD) study, I explore the pathogenicity of this type of …
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Innate sensing and regulation during enteric caliciviruses infections
… a robust interferon response to infection with MNV1 in primary BMDMs and RAW264.7 cells, with a significant increase in viral titres following infection in RIG-I- and STING-deficient cells. We also show that STING is non-canonically activated in MNV1-infected cells partly in a RIG-I dependent …
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Mechanism of biosynthesis of the dimanganese-tyrosyl radical cofactor of class lb Ribonucleotide reductase
… to and reacts with Mn"2-NrdF to form a Mn" Mnv intermediate, which oxidizes tyrosine to Y·. Finally, we also demonstrate that E. coli NrdF, when incubated anaerobically with Mn" and Fe" and then exposed to H202 , forms an active Y·-containing metallocofactor that we suggest is Fe"Mn'l-Y·. …
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Investigating behaviors of zoonotic and human pathogens on plants
… Col-0 plants were inoculated with either MNV, TV, human norovirus GII.4 or HBSS (control). The results of these studies suggest that the jasmonic acid pathway of plant defense is likely involved in the plant immune response to human norovirus. This research provides the first pieces of …