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Showing 1 to 17 of 17 for “"MNNG"”.
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Mutational spectra of MNNG and ICR-191 in human cells
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1988.
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Transcriptional response of O⁶-methylguanine methyltransferase deficient yeast to methyl-N-nitro-N-nitrosoguanidine (MNNG)
… genes in both WT and mgtl in response to MNNG is an unexpected result that could signify a successful recovery following wide-spread cellular damage.
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SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in Gastric Mucosa
… is, to a large extent, mediated by NIS. NIS in MNNG-induced tumours: Gastric cancer was chemically induced in rats by the administration of N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) in the drinking water. Multiple microadenomas as well as large adenomas were found in the stomachs of all …
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ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS
… SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION WHEN THEY ARE ADMINISTERED AT STAGES B OR C. B) . THE ABOVE CARCINOGENS CAN INHIBIT THE REGENERATION OR DISTURB THE SCELETAL …
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A study of inter-individual differences in the DNA damage response
… temozolomide and methylnitronitrosoguanidine (MNNG). While MNNG has been extensively studied as a model DNA damaging drug, temozolomide is used in the clinic today to treat astrocytoma and glioblastomas. The two drugs are often referred to as functional analogues. We wanted to see if the cell …
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
Four human osteosarcoma cell lines (MNNG, TE85, MG63, and G292) and a human-derived osteosarcoma metastatic to murine lung (MLM) were transduced "in vitro" using retroviral vectors containing the Herpes simplex thymidine kinase (HS-tk), human interleukin 2 (IL2). and B-galactosidase (BAG) genes. …
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Development of a collagen gel sandwich hepatocyte bioreactor for detecting hepatotoxicity of drugs and chemicals
… N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), methyl methane sulfonate (MMS), cadmium, vinyl acetate and dimethylformamide (DMF). The cells were sensitive to aflatoxin B1, MMS, MNNG and cadmium. However, they were
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A functional genomics approach: Characterisation of two Non-ribosomal peptide synthetase genes, and investigation of an adaptive response towards alkylating DNA damage in Aspergillus fumigatus.
… (e.g. N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)) was identified in A. fumigatus. Afmpt is a transcriptional regulator for this response, and exposure to MNNG causes up-regulation of Afmpt and Afagt, an alkylguaninetransferase. Afmpt and Afagt functions were confirmed through targeted gene …
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Isolation and characterization of a chitinase-secreting mutant of mortierella pusilla with altered interaction with the mycoparasite piptocephalis virginiana
… sUbjected to N-methyl-N'-nitro-nitrosoguanidine (MNNG). To attain a high mutation frequency , a 1o-minute exposure to 10 mg/ml MNNG was used and lead to the survival of about 10 % of the spores. The exposed spores then were plated on chitin or milk plates. Approximately 30,000 colonies were …
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Understanding cell fate decisions in response to 0⁶-Methylguanine DNA lesions
… agent N-methyl-N'-nitro-Nnitrosoguanidine (MNNG). A systems-level approach combining various experimental techniques was used to quantitatively monitor the temporal regulation of DDR network proteins and, in parallel, phenotypic responses (cell cycle arrest, DNA replication, and apoptosis) …
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Characterization of O6-Methylguanine DNA Methyltransferase and Base Excision DNA Repair Activity in Xiphophorous Fishes
… MNU, N-methyl-N-nitro-N nitrosoguanidine; MNNG) produces a wide spectrum of DNA adducts. The most frequent base adducts formed by alkylating agent exposure include those produced by alkylation of purine nucleophilic centers (N7 and N3 alkylpurines). Alkylation at the 06 position of guanine …
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Caracterização molecular da mutação pso8-1/rad6 de Saccharomyces cerevisiae, sensível à fotoadição de psoralenos, à radiação UVC e a mutágenos químicos
… de psoralenos mono- e bi-funcionais, à UVC e ao MNNG, complementou o fenótipo de sensibilidade à fotoadição de psoralenos conferido pelas mutações pso1 a pso7 e assim foi chamado pso8-1. O duplo mutante pso8-1 rad4-4 foi altamente sensível à UVC, indicando assim uma interação sinergística dos …
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Der Einfluss von HtrA2/Omi auf AIFM1 und MIF in der Zelltodmodalität Parthanatos
… Wildtyp-, als auch in den Knockout-Zellen unter MNNG- beziehungsweise H2O2-Stimulation. Folglich resultiert der Schutz von HtrA2/Omi-Knockout-Zellen vor Parthanatos vermutlich nicht aus einer verringerten Kernmigration von AIFM1 und MIF. Der anfangs vermutete Einfluss des Proteins XIAP wurde …
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Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
… for HR alone were 5-fold more sensitive to MNNG (N- methyl-NOe-nitro-N-nitrosoguanidine), a prototypical methylating agent, and 6-thioG. Interestingly, loss of MMR alleviated the sensitivity of HR-deficient cells, which suggests that MMR dependent processing generates damaged DNA …
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Synthetic approaches to the understanding of DNA nucleobase methylation
… (MNU), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), etc. N7-methyl-2'-deoxyguanosine (N7-methyl-dG, or ^{7Me}dG) adduct is the most abundant DNA methylation products for most methylating agents. DNA polymerase actions on ^{7Me}dG are difficult to study due to its instability against ring- …
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The role of cancer stem cells in osteosarcoma
… OS cell lines (143B, Cal72, G292, HOS, MG63, MNNG-HOS, U2OS and SaOS-2) along with the breast cancer cell line MCF7 have been analysed for the presence of sub-population of cells expressing putative CSC markers (aldehyde dehydrogenase and CD117). The intracellular enzyme aldehyde dehydrogenase …
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Erfassung von mutagenen und rekombinogenen Effekten durch die Hefe 'Saccharomyces cerevisiae'
… well-known effect provided the expected results. MNNG and UV-radiation led mainly to the increase of the mutation frequency. To a smaller extent frequencies were induced by gene conversions and crossing over events. An effect caused by ethidiumbromide or benomyl could not be proven under the …