Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MN9D"”.
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Auswirkungen des LRRK2-Knockdown durch RNA-Interferenz auf die murine dopaminerge Zelllinie MN9D
… des LRRK2 in mesenzephalen, sogenannten MN9D-Zellen reduziert werden, indem der Mechanismus der RNA-Interferenz in vitro durch Transfektion von siRNA angestoßen wird. Durch die Reduktion der LRRK2-Aktivität sollen Veränderungen in den MN9D-Zellen induziert und diese objektiviert werden. …
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Degenerative mechanism in dopaminergic neurons
… dopaminergic cell line of mesencephalic origin, MN9D, and the Parkinsonism-causing neurotoxin MPP+ (1-methyl-4-phenylpyridinium ion), as a model. In this study, necrosis did not appear to be involved. Characteristics of apoptosis such as chromatin condensation were evident. However, caspase-3 did …
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Role of metabolic stress in the selective vulnerability of dopaminergic neurons
… We used mouse dopaminergic hybridoma cell line MN9D cells to model the effects of rotenone and Antimycin A (AA) exposure on mitochondrial function and dopaminergic neuronal death. MN9D cells, which express endogenous tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine biosynthesis, …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… cytotoxic effects on dopaminergic neuroblastoma MN9D cells when activated in vitro. I also demonstrated that microglia isolated from TNF-null mice failed to display the expected morphological changes in response to LPS stimulation, including enhanced perinuclear expression of the activation …
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Design, Synthesis, Biological Evaluation And Molecular Modeling Studies Of Novel Multifunctional Neuroprotective Drugs For The Treatment Of Parkinson's Disease: An Effort Towards The Improvement Of In Vivo Efficacy And Modulation Of Alpha Synuclein Aggregation Property Of The Neuroprotective Parent
… in MTT assay lead compounds are able to protect MN9D cells from the exposure to neurotoxin MPP+ and 6-OHDA in a dose dependent manner. </p> <p>Compounds D-519 and D-520 were selected as lead molecules from the second series and they exhibited nanomolar to sub nanomolar range affinity at D2/D3 …
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Progress Towards Understanding Of Mechanisms Of Action Of Potent Multifunctional Disease Modifying Therapeutics For Parkinson's Disease & Investigating The Methamphetamine-Induced Striatal Microglia Activation.
… secreted by cultured dopaminergic cell line (MN9D cells). We also verified the differences in protein expression profile of BV2 cells alone or BV2 cells co-cultured with dopaminergic neuronal cell line to determine if either of the cell-culture systems can be used as a model to determine …