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Showing 1 to 2 of 2 for “"MMV1803522"”.
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Further Exploring the Structure Activity Relationship (SAR) of MMV008138 and MMV1803522
… studied over the years. (1S,3R)-MMV008138 and MMV1803522 are two compounds that have been studied in the Carlier Group. My research focused on the structural variation of each of these compounds, in the hope that greater potency could be realized. Chapter 2 describes my work on …
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Hit to Lead Stage Optimization of Orally Efficacious β-Carboline Antimalarials
… mino)ethyl)-9H-pyrido[3,4-b]indole-3-carboxamide (MMV1803522) was observed in the synthesis of (1S,3S)- and (1R,3R)-TCDMC-140230. This achiral β-carboline amide (PRC1584, IC50 = 108 ± 7 nM) proved more potent towards P. falciparum than MMV008138 and its toxicity was not reversed by co-application …