Global ETD Search
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Showing 1 to 7 of 7 for “"MMR deficient"”.
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Role of The Immune System In The Modulation of The Mmr-Deficient Intestinal Stem Cell Niche
<p>Mismatch Repair (MMR) is a crucial DNA repair system to maintain genomic integrity in cells that is integrated by specific genes including <em>MLH1</em>, <em>MSH2</em>, <em>MSH6</em>, and <em>PMS2. </em>These genes play a critical role in repairing errors that occur in base pairing by …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
… Studies have attempted to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response to 5-FU therapy. However, no difference in long term response or survival after 5-FU treatment between patients with MMR-proficient and MMR-deficient tomours were detected.
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Genomic and Transcriptomic Landscape of Colorectal Premalignancy
… premalignant lesions with DNA mismatch repair (MMR) deficient and proficient background using RNAseq. My results showed an activated immune profile despite low mutational and neoantigen rate, which challenges the canonical view in MMR-deficient carcinoma stage that immune activation is largely …
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The Crosstalk Between DNA Mismatch Repair and Replication
… fidelity relies on DNA mismatch repair (MMR) and the proofreading nuclease activity of DNA polymerases. Normally, biosynthetic errors can be removed by the polymerase's proofreading nuclease activity upon their incorporation, and those errors that have escaped the proofreading nuclease …
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Elucidation of the occurrence of extracolonic cancers in Lynch syndrome
… disorder resulting from mutations within DNA MMR genes. Effective surveillance, diagnosis and treatment of the disorder is complicated due to the phenotypic and genetic heterogeneity of lynch syndrome, which exhibits an autosomal dominant mode of inheritance. Determine the molecular pathology …
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The Role of Arabidopsis thaliana Mismatch Repair Proteins in Meiotic Recombination
… proteins with roles in DNA mismatch repair (MMR) are known to influence meiotic recombination in several eukaryotes. In Arabidopsis thaliana this includes three MSH heterodimers (MSH2-MSH3, MSH2-MSH6 and MSH2-MSH7) that recognise mismatched nucleotides and have demonstrated roles in …
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Mismatch Repair Deficient Tumors Lacking Known Sporadic Causes: Are They All Due to Lynch Syndrome?
<p>BACKGROUND: Mismatch repair deficient (MMRD) colorectal (CRC) or endometrial (EC) cancers in the absence of <em>MLH1 </em>promoter hypermethylation and <em>BRAF</em> mutations are suggestive of Lynch syndrome (LS). Positive germline genetic test results confirm LS. It is unclear if individuals …