Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"MMP9"”.
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The Treatment of Breast Cancer Tumor Growth and Metastasis With an Anti-MMP9 DNAzyme
<p><strong>BACKGROUND:</strong> Tumor cell proliferation, invasion and metastasis are known to be mediated, at least in part, through degradation of basement membrane by neutral metalloproteinases (MMP) produced by tumor and stromal cells. MMP-9 is known to play a significant role in breast tumor …
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Die MMP9- und OPG-Expression von dermalen Fibroblasten und mesenchymalen Stammzellen nach Stimulation durch Myelom- und Hodgkinzelllinien
… domain of angiogenesis of carcinomas, especially MMP9. The attempts of fibroblaststimulation by the hodgkin-cellline HDLM2 showed a manifest increase of MMP9-expression. Both experiments proved the importance of mesenchymal cells in tumor pathogenesis in cases of multiple myeloma and hogdkin …
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Immunolocalozzazione epatica e livelli plasmatici di mmp9 nella steatoepatite e nell'epatite C cronica e nella steatoepatite non alcolica
… l'espressione e la localizzazione della MMP9 in pazienti con NASH, e con epatite da virus C (HCV), una altra condizione che, se cronicizzata, può indurre fibrogenesi nel parenchima epatico. [34] Il nostro obiettivo principale e' stato quello di studiare la possibile utilità diagnostica …
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Delineating the metastatic process in osteosarcoma; the role of bone cells, the cell environment and autophagy
… expressed genes were validated by RT-qPCR; MMP9 (2.4-fold decrease; p≤0.001), MMP14 (2-fold decrease; p≤0.01), CSF3 (2.5-fold decrease; p≤0.01) and SPOCK (1.6-fold decrease; p≤0.01). In an attempt to mimic OC-conditioned media, chemical inhibitors of MMP9 and STAT3 (downstream of CSF3) were …
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Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells
… B receptor (NMBR), matrix metalloproteinase‑9 (MMP9), and neuraminidase‑1 (Neu1) to modulate cancer‑associated phenotypes in breast cancer cells. Using sialidase assays, we found that caffeine induced Neu1 enzymatic activity in both MDA‑MB‑231 (TNBC) and MCF‑7 (luminal) cells in a dose‑dependent …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… 1 (Neu1) and matrix metalloproteinase 9 (MMP9). This crosstalk facilitated the glycosylated receptor activation and downstream gene regulation mediated by nuclear factor kappa B (NF-κB). Importantly, cannabinoid type 1 (CB1) receptors have been implicated in this novel biased signaling …
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Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis.
… cellular entry. Increased expression of MMP2 and MMP9, amongst others, has been shown previously in autopsied MS brain, and increased levels of the cell surface peptidase CD26, expressed by T cells and endothelial cells, have been linked to disease activity. Interactions between proteases and …
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Modulating metalloproteinase activity with protein nanofibrils
… excessive proteolytic activity, especially of MMP9, results in non-healing chronic wounds by degrading newly formed extracellular matrix and other required proteins. Thus, controlled activity of MMPs is essential for systematic wound healing. The development of new and efficient biomaterials in …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
… (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó mediante cocultivos de los CAFs con dos líneas celulares de cáncer de mama (MCF7 y MDA-MB-231), la posible existencia de una influencia recíproca en la expresión de estos …
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Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response
… Gαi subunit and matrix metalloproteinase 9 (MMP9) by using specific inhibitors. In addition, TQ was found to induce sialidase activity in Toll-like receptor-deficient HEK293 cells. These latter data suggested that TQ may be activating GPCR Gαi and MMP9 signaling associated with Neu4 sialidase …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… a 2.56-fold (p<0.05) fold increase on MMP2 and MMP9 genes compared to WT and NC HOS-143B cells respectively. However, in the in ovo environment, a reduction of 20.17-fold (p<0.001) and 14.31-fold (p<0.05) on MMP2 and MMP9 genes was seen compared to WT and NC HOS-143B tumours, suggesting that …
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Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
… and the expression/proteolytic activity of MMP9. I have further shown that Src family kinase-dependent Tks5 phosphorylation is necessary for podosome formation and matrix degradation activity in macrophages. A similar investigation was carried out on the invadopodia of prostate cancer cell …
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Asthma: Cytokine-Induced Over-Expression of Matrix Metalloproteases Compromises Airway Epithelium Tight Junctions and a Clinical Case Study
… expression of matrix metalloprotease 9. MMP9 encourages detachment-induced cell death - anoikis - which results in a structural change compromising the airway epithelium's ability to act as a primary immune defense mechanism. The chronic characterization of asthma results because of an …
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Role of matrix metalloproteinases in regulation of late embryonic healing process
… of four mmps: mmp1.L, mmp7.S, mmp8.S, and mmp9.L. Injury or amputation caused the upregulation and their expression level peaked at 3-6 hours post injury which corresponds with late phase of healing. Thus, I focused on...
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3D Cell Culture in Microgels: A Novel Screening Platform for Disease Modelling and Drug Testing
… the microgel to study certain cell behaviours. A MMP9-sensitive peptide was incorporated into biotin-agarose microgels to investigate cell invasiveness. In this way, MDA-MB231 cells were shown to secrete more active MMP9 than MCF7 cells, which was also confirmed by RT-qPCR of both cell lines …
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Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma
… and upregulation of matrix-metalloproteinase 9 (MMP9) activity. In an invasion inhibitor screen of 25 drugs, we identified 5 drug hits that significantly reduced HL TAM invasion; one of these drug hits, currently approved for treating autoimmune diseases, both decreased invasion and enhanced the …
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Potential roles for transforming growth factor-B during terminal differentiation of ocular lens cells /
… induced MMP activity corresponding to MMP2, MMP9 and an unknown MMP at approximate 77 kD molecular weight. Thus, TGF-β does not function to keep CLAP cells withdrawn from the cell cycle or to promote fiber cell differentiation. TGF-β does induce CLAP cells to produce ECM proteins and matrix …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… generation of matrix metalloproteinase 9 (MMP9), chemokine, CXCL2, and the recruitment of MCs and inflammatory cells in control mice but these responses were substantially reduced in GRK2-deleted mice. IgE-mediated anaphylaxis and itch were also significantly reduced in the absence of GRK2. …
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Tumour Associated Neutrophils as a Potential Biomarker for Anti-PD-1 Immunotherapy in Non-Small Cell Lung Carcinoma: An Automated Approach
… of potentially targetable neutrophil proteins (MMP9, ARG1, ELANE, PADI4, S100A9). The automated TAN classifier achieved high accuracy (92.8%) and an AUC of 0.931 in internal CPTAC 5-fold cross-validation and identified a biologically relevant neutrophil-rich subgroup in an external cohort with …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… of pro-invasive molecules, such as MMP2 and MMP9, than their Tie2 negative counterparts and are able to increase glioma cell invasion <em>in vitro, </em>suggesting an active role of these cells in the invasive process observed after treatment. Furthermore, we have shown that expression of …
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