Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"MMP2"”.
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The mechanism of action of the scorpion toxin, chlorotoxin, a bioinformatics approach
… current treatment. Matrix metalloproteinase 2 (MMP2) is upregulated in glioblastoma multiforme (GBM) and its high expression is directly correlated with invasion and metastasis of GBM cells. Annexin A2 is involved in angiogenesis, and it is overexpressed in GBM. MMP2 and annexin A2 are potential …
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Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma
… CUL4B and not CUL4A knockdown reduced TGF-β1 and MMP2 expression, suggesting a unique association of CUL4B with this pathway. However, the treatment of PM cells with exogenous TGF-β1 following CUL4B knockdown did not rescue PM cell growth. The work further analyzed ACC Meso-1 xenograft tumor …
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Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis.
… cellular entry. Increased expression of MMP2 and MMP9, amongst others, has been shown previously in autopsied MS brain, and increased levels of the cell surface peptidase CD26, expressed by T cells and endothelial cells, have been linked to disease activity. Interactions between proteases …
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Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
… in metalloproteinase (MMPs) activity, especially MMP2 and MMP9. MMPs are extracellular matrix-degrading enzymes able to degrade elastin, a process known to be involved in the development of aortic dilatations (aneurysms) and dissections. Therefore, finding ways to increase SirT1 activity in the …
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Matrix Metalloproteinases 2 and 9 in Normal Canine Cerebrospinal Fluid
… such as arthritis, neoplasia and CNS diseases. MMP2 is known to be constituitively produced in CSF while MMP 9 is present only in certain pathologic conditions such as multiple sclerosis, neoplasia and inflammatory diseases. We hypothesize that MMP2 is present in normal canine CSF while MMP 9 is …
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Changes in serum histologic surrogate markers and procollagen III N- terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy
… III N-terminal peptide (PIIINP) and TIMP1, MMP2, hyaluronic acid and cytokeratin 18 fragment levels were significantly decreased and the haptoglobin level was significantly increased from baseline after entecavir treatment. Multivariate analysis identified PIIINP (P=0.028) and the initial …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… and a 2.56-fold (p<0.05) fold increase on MMP2 and MMP9 genes compared to WT and NC HOS-143B cells respectively. However, in the in ovo environment, a reduction of 20.17-fold (p<0.001) and 14.31-fold (p<0.05) on MMP2 and MMP9 genes was seen compared to WT and NC HOS-143B tumours, suggesting …
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EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… fibrotic markers (e.g., collagen I, -SMA, MMP2/MMP9, and TIMP-1,) using human hepatic stellate cells (HSC), LX-2 cells, at both mRNA and protein level by real-time PCR and ELISA/western blot, respectively, demonstrated that Gefitinib had the greatest ability to attenuate HSC activation and …
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Untersuchungen zur Pathobiochemie der extrazellulären Matrix bei Pseudoxanthoma elasticum (PXE)
… 29 polymorphisms in four candidate genes, namely MMP2, MMP9, MMP14 and VEGFA, have been examined in this study. Comparison of allelic frequencies showed association of the polymorphisms c.-1575G>A, c.-1306C>T and c.-790T>G in the promoter of the MMP2 gene with PXE. Additionally, polymorphisms in …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
… quimiocinas (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó mediante cocultivos de los CAFs con dos líneas celulares de cáncer de mama (MCF7 y MDA-MB-231), la posible existencia de una influencia recíproca en la expresión de …
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Modulating metalloproteinase activity with protein nanofibrils
… to MMP1 (40 %) was observed compared to MMP2 (> 50 %) and MMP9 (> 70 %). Furthermore, the ability of PNFs to inhibit MMP catalytic activity (> 50 % for MMP1, > 70 % for MMP2 and 9) was confirmed using a chromogenic substrate. The selectivity for MMPs observed here could potentially be due …
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Characterisation and modulation of the gelatinase system of human Bruch's membrane
… EGTA resulted in the release of active forms of MMP2 and significantly improved the fluid transport properties of the membrane (p<0.005).
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Abdominal aortic aneurysms : identification by self-examination and analysis of variation in matrix metalloproteinases with peak wall stress
… difference was found between the 2 sites for MMP2, 8, 9, TIMP1 or 2.These findings suggest either that the peak stress and rupture sites are geographically different, or that the event of rupture is temporally related to a fundamental biochemical change.
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Potential roles for transforming growth factor-B during terminal differentiation of ocular lens cells /
… TGF-β induced MMP activity corresponding to MMP2, MMP9 and an unknown MMP at approximate 77 kD molecular weight. Thus, TGF-β does not function to keep CLAP cells withdrawn from the cell cycle or to promote fiber cell differentiation. TGF-β does induce CLAP cells to produce ECM proteins and …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… and activity of pro-invasive molecules, such as MMP2 and MMP9, than their Tie2 negative counterparts and are able to increase glioma cell invasion <em>in vitro, </em>suggesting an active role of these cells in the invasive process observed after treatment. Furthermore, we have shown that …
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The Role of Receptor Tyrosine Kinase Axl In Pancreatic Ductal Adenocarcinoma and Its Regulation By Hematopoietic Progenitor Kinase 1
… Akt and NF-κB activation and up regulation of MMP2 were involved in the invasion, migration and survival of PDA cells. Thus, we demonstrate that Axl plays an important role in the development and progression of PDA. Targeting Axl signaling pathway may represent a new approach for the treatment …
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Zinc ion fluxes on the pathway to mammalian sperm fertilization competency
… the inner acrosomal membrane metalloproteinase MMP2 that had a severely reduced activity in the presence of Zn2+ by gel zymography. In context of the fertilization-induced oocyte zinc spark and the ensuing, oocyteissued polyspermy-blocking zinc shield, the inhibitory effect of Zn2+ on spermborne …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
… samples. Both matrix metalloproteinases (MMP's), MMP2 and MMP9 were significantly decreased in the D3KO LV cardiac fibroblasts. Finally, known profibrotic marker, transforming growth factor [beta]1 (TGF-[beta]1), and the angiotensin II receptor type I were examined. In the D3KO LV cardiac …
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TIMP-1: Zelluläre Funktion und Beeinflussung der Genexpression von Matrix-Metalloproteinasen in humanen Hepatomzellen
… pathways are involved in the regulation of MMP2 and MMP9 gens as well as how they are influenced by TIMP-1. For this purpose both certain kinases as well as their phosphorylated form (STAT 1, P-STAT 1, STAT 3, P-STAT-3, JAK 1, P-JAK 1, JAK 2, P-JAK 2, Ras GAP and JNK 1) were investigated by …
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Human trophoblast survival and invasion in the developing placenta: autocrine regulation by hbegf
… In addition, a cascade involving MMP2 exists that leads to HBEGF shedding and its autocrine signaling at 2% O<sub>2</sub>. It also signals through ERBB receptors to induce an autocrine post-transcriptional increase in its own protein levels through the ERK, MAPK14 or JNK pathways. …
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