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Showing 1 to 20 of 80 for “"MMP-2"”.

  1. Imagerie moléculaire de la MMP-2

    Lebel, RéjeanUniversité de Sherbrooke2012

    Les métalloprotéinases de matrice (MMPs) sont des enzymes impliquées dans la restructuration tissulaire et la migration cellulaire. La MMP-2, en particulier, a été reconnue comme biomarqueur de la progression ou du pronostic de plusieurs pathologies, comme l'arthrite, l'athérosclérose, l'infarctus …

    sherbrooke Repository record

  2. Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum

    Zhang, Bo

    <p>Matrix metalloproteinases (MMPs) have been postulated to be important for angiogenesis and for tissue remodeling events associated with corpus luteum (CL) development. The MMPs are mainly regulated at three levels, transcription, activation, and inhibition by endogenous tissue inhibitors of …

    unh-thes Repository record

  3. Effect of Methamphetamine on Gingival Fibroblast Production of Matrix Metalloproteinase (MMP)-2 and -9 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 and -2 In Vitro

    Farooqi, Owais Ali2016

    … and periodontitis. Matrix metalloproteinases (MMPs) produced by gingival fibroblasts degrade the extracellular matrix (ECM) and play an important role in periodontitis and oral cancer metastasis. There is no information on effects of METH on fibroblast MMP production, or its role in …

    tenn-hsc Repository record

  4. Effects of systemic flunixin meglumine, topical oxytetracycline, and topical prednisolone acetate on tear film proteinases innormal horses

    Rainbow, Marc E.Virginia Tech2004

    … of two proteinases, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), in equine tear film. The study design consisted of twelve ophthalmically normal horses separated into three groups of four in a cross-over study design. Each group was treated for 5 days with flunixin …

    vt Repository record

  5. The Expression of Matrix Metalloproteinase-9 and -2 in Olfactory Injury and Recovery

    Bakos, Stephen2015

    … remain unknown. The matrix metalloproteinases (MMPs) are important components in many central nervous system (CNS) injury paradigms, yet remain unexplored in olfactory injury and recovery. To address the role of MMPs, the temporal expressions of MMP-9 and MMP-2 were examined in 3 olfactory …

    vcu Repository record

  6. Visualizing the Spatial Localization of Active Matrix Metalloproteinases (MMPs) using MALDI Imaging MS

    Muruganantham, Sasirekha2016

    … chemokines, and matrix metalloproteinases (MMPs). The nature of the FBR requires the spatial and temporal regulation of these mediators. MMPs are an extremely large and diverse group of enzymes that play key roles in regulating the FBR. Precise spatiotemporal regulation of MMPs defines their …

    arkansas Repository record

  7. The Examination of Leptin Receptors, Matrix Metalloproteinases-2 and -9 and Tissue Inhibitors of Metalloproteinases in the Rat Cervix

    Rivera, AlexanderUniversity of Illinois at Urbana-Champaign2015

    … has a role in regulating two metalloproteinases (MMP-2 and -9), enzymes known to be involved in collagenolysis. Furthermore, the expression of these metalloproteinase enzymes and their associated inhibitors was examined. Results reported herein show that three of five leptin receptor isoforms are …

    uiuc Repository record

  8. Untersuchungen über die vorteilhaften und nachteiligen Effekte einer späten Reperfusion auf das Remodeling im Restmyokard nach Koronarocclusion bei der Ratte

    Meyer, Bernd JosefUniversität Würzburg

    … für Fibronectin (FN), Matrixmetalloproteinasen (MMPs) und Tissue inhibitors of MMPs (TIMPs) zeigte eine unterschiedliche Expression nach Myokardinfarkt und Reperfusion. Eine Woche nach dem Infarkt kam es zu einer signifikanten Reduktion von TIMP-1, nicht aber von TIMP-2 in allen Infarktgruppen. …

    wurz-thes Repository record

  9. Matrix Metalloproteinases Regulate The Differentiation Of Adipose-Derived Mesenchymal Stem Cells Into Endothelial Cells

    Almalki, Sami G.Creighton University2017

    … prevent restenosis. Matrix metalloproteinases (MMPs) have critical role in the differentiation of MSCs to different lineages. Identifying the molecular factors and mechanisms that regulate AMSCs differentiation to endothelial cells (ECs) is important in the promotion of a greater understanding …

    creighton Repository record

  10. Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis

    Fugler, Lee AnnBiomedical and Veterinary Medical Sciences - Veterinary Clinical Sciences2022

    … this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of equine MMPs and evaluation of the effectiveness of MMPIs in the horse are needed. Equine MMP-9 was harvested from …

    lsu-thes Repository record

  11. Valutazione dell'attività delle metalloproteinasi 2 e 9 nelle urine e nel tessuto renale di cani normali e affetti da nefropatia

    Mancini, Danilo <1976>Alma Mater Studiorum - Università di Bologna2008

    Matrix metalloproteinases (MMP) are a large family of proteinases that remodel extracellular matrix (ECM) component. Recent data suggest a role for MMPs in a number of renal pathophysiologies, associated with an imbalance of ECM syntesis and degradation, which may result in an accumulation of ECM …

    bologna Repository record

  12. TIS21 inhibits cell migration and invasion

    임, 서경2011

    … FoxM1 phosphorylation and downregulated MMP-2 expression. In conclusion, TIS21 inhibited cell migration and invasion by inhibition of Src by downregulation of ROS generation in mitochondria, furthermore, TIS21 inhibited FoxM1 phosphorylation and decreased MMP-2 expression. AKT interacted …

    ajou Repository record

  13. Molecular Mechanisms of Interleukin-1beta-Stimulated Regulation of Angiogenesis in Cardiac Microvascular Endothelial Cells.

    Mountain, Deidra Jill Hopkins2007

    … and wound healing. Matrix metalloproteinases (MMPs) are implicated in angiogenesis because of their ability to selectively degrade components of the extracellular matrix. Vascular endothelial growth factors (VEGFs) play a vital role in angiogenesis because of their involvement in the …

    etsu Repository record

  14. The role of matrix metalloproteinases and their inhibitors in irinotecan-induced oral mucositis: an animal model.

    Al-Azri, Abdul Rahman2013

    … enzymes called matrix metalloproteinases (MMPs) have been recently postulated to play a part in mediating the damaging process seen in oral mucositis. It is well established that MMPs and their naturally existing inhibitors (tissue inhibitors of metalloproteinases; TIMPs) maintain a …

    adelaide Repository record

  15. Comparison of Plasma MMP and TIMP Concentration Related to Albumine Excretion Rate in Type 2 Diabetes

    안, 상미2011

    … 단백뇨 군 20명으로 대상으로 병력 청취, 신체 계측을 시행하고 ELISA법으로 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정하였다. 결과: 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정한 결과 MMP-2와 MMP-9의 농도는 각 군에서 차이를 보이지 않았으며 TIMP-1은 단백뇨가 많이 배설되는 군 일수록 통계학적으로 유의하게 혈청 농도가 증가되는 결과를 나타내었다. 결론: 당뇨병성 신증의 특징인 세포 외 기질의 분해 감소 및 침착 증가가 일어나는 과정에서 TIMP-1이 영향을 미칠 것으로 보인다. "

    ajou Repository record

  16. The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling

    Mcclung, Heather M.2011

    … expression of the matrix metalloproteases (MMPs) MT1-MMP and MMP-2. We also demonstrate that SPARC increases MMP-2 activation and the secretion and processing of galectin-3, a known target of MMPs. To investigate the roles of specific domains, we used a SPARC-GFP fusion protein and deletion …

    wayne-thes Repository record

  17. HGF als anti-fibrotisches Agens: Effekte der Überexpression in renalen Fibroblasten und Tubulusepithelzellen

    Rogge, Cathleen2012

    … wurde die proteolytische Aktivität der Proteasen MMP-2 und MMP-9 in Zellkulturüberständen zymographisch ermittelt. Bei den NP1-Zellen konnte eine durch HGF-Überexpression gesteigerte Aktivität für MMP-2 (28%) und MMP-9 (32%) nachgewiesen werden. Im Gegensatz dazu zeigte sich bei den …

    goettingen Repository record

  18. The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.

    Jesudoss, Jesintha RoseRobert Gordon University2017

    … to be substrate specific for either legumain or MMP-2/9 were synthesized. This was achieved via a combination of both solid and solution phase peptide synthesis. The first phase of the research study focused on the synthesis of a targeted MRI contrast agent designed to image legumain expressing …

    rgu Repository record

  19. Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631

    Badeaux, Kathleen S.2002

    … proteinases: matrix metalloproteinases (MMPs) and components of the urokinase plasminogen activator (uP A) system. Our studies include RT-PCR of CRL-1631 eDNA revealing mRNA for MMP-2, MMP-9, TIMP-1, TIMP-2 and uPAR. MMP-2 and MMP-9 activity was verified by gelatin zymography. TIMP-1, …

    tdl Repository record

  20. Efeito da sinvastatina na modulação da expressão de Reck e suas isoformas em células de melanoma humano

    Barbosa, Fernanda Augusta de Lima2010

    … pela acao das metaloproteinases de matriz (MMPs), que degradam a matriz extracelular, favorecendo a invasao. Entre os elementos que podem regular a atividade de MMPs esta RECK, uma glicoproteina ancorada a membrana celular. Tendo em vista que as estatinas sao drogas que inibem a sintese de …

    parana Repository record

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