Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"MMP-1"”.
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Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas
… in normal brain, matrix metalloproteinase-1 (MMP-1) has been shown to be present in gliomas, and in particular in glioblastoma multiforme (GBM). To begin to examine the role of MMP-1 in these tumore, two human glioma cell lines were stably transfected with MMP-1 cDNA. Confirmation of MMP-1 …
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Regulation of Matrix Metallopeptidase-1 in Breast Cancer Metastasis
Matrix Metallopeptidase 1 (MMP-1) expression has repeatedly been correlated to tumorigenesis and metastasis. Yet, MMP-1 regulation in a metastatic context remains largely unknown. Here we confirm differential MMP-1 expression in mammary carcinoma cells with varied metastatic potentials and identify …
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The Influence of a Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter on Glioma Biology
… include the matrix metalloproteinase family. MMP-1 is a member of this family which has been well studied in many types of invasive tumors, with gliomas being an exception. We studied a single nucleotide polymorphism (SNP) in the MMP-1 promoter that may influence glioma biology. This SNP …
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Investigation of the host-mediated proteolytic response to pulmonary Mycobacterium Avium Complex infection
… by host-derived matrix metalloproteinases (MMPs). Unlike Mycobacterium tuberculosis (MTb) infection, the mechanisms of tissue destruction during MAC infection are not well-characterised. Here, I aim to elucidate if MMPs are upregulated during MAC infection, and how MMP upregulation is …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… tb). Upregulation of matrix metalloproteases (MMPs) has been documented in patients with tuberculosis (TB), while their tissue inhibitor (TIMPs) levels remained the same. Animals which can develop cavities have well-conserved MMP-1 orthologs suggesting a pivotal role of MMP-1 in cavitation. The …
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Extracellular Matrix Metalloproteinase Inducer (Emmprin) Regulates Matrix Metalloproteinases in Human and Baboon Uterine Endometrium
… cells secreted a full-length functional form of EMMPRIN that stimulated stromal expression of MMP-1,-2 and -3 but not EMMPRIN. We also found that endogenous stromal cell expression of EMMPRIN was important but not required for MMP stimulation.
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Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα
… παραγωγή διαμεσολαβητών, όπως η IL-6 η MMP-1, η MMP-3 το κολλαγόνο τύπου-Ι και ο TIMP-1, που εμπλέκονται στη παθογένεια του ρινικού πολύποδα (ΡΠ). Ο MIF ανιχνεύθηκε στο μέσο καλλιέργειας όλων των ιστών και σε όλα τα εκχυλίσματα. Η έκφρασή του ήταν αυξημένη στον ρινικό πολύποδα σε σχέση …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
… for TGF-β1-induced matrix metalloproteinase (MMP)-1 expression, the most characterised MMP in wound healing, suggesting that TREM-2 may be required for the beneficial effects of TGF-β1 on wound healing by regulating MMP-1. An in vitro model of ischemia in stroke was then established to study …
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Documentation, anti-aging activities and phytochemical profiling of selected medicinal plants used by Jakun women in Kampung Peta, Mersing, Johor
… which are matrix metalloproteinase-1 (MMP-1) inhibition, elastase inhibition, tyrosinase inhibition, acetyl- and butyrylcholinesterase inhibition assays. Single formulation of U. micrantha showed the highest inhibition towards MMP-1 (49.44 ± 4.11 %) and elastase enzymes (20.33±2.52%), …
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Auswirkungen der maternalen HIV-1-Infektion auf die Genexpression endothelialer Vorläuferzellen und differenzierter Endothelzellen nicht-infizierter Kinder
… die Expression von Matrix-Metalloprotease-1 (MMP-1) unter der Nachweisgrenze liegt oder signifikant reduziert ist. Dies konnte auf RNA- und Proteinebene sowie mittels Gelatine-Zymografie bestätigt werden.
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Lipoteichoic acid from Staphylococcus aureus induced expression of MMP-9 in human middle ear epithelial cells
Change in matrix metalloproteinases (MMPs) and regulation of their tissue inhibitors of metalloproteinases (TIMPs) could play certain role in the pathogenesis of otitis media. This study was designed to evaluate the modulation of MMPs and TIMPs in middle ear epithelium by lipoteichoic acid (LTA) …
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The Possible Role for Basigin Receptor Function in The Induction of Matrix Metalloproteinase Expression in Human Endometrial Stromal Cells
… Basigin has been shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help researchers understand how these signaling cascades flow in the framework …
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Can curcuminoids be more effective than sulfasalazine for the treatment of rheumatoid arthritis?
… CXCL12, CYTL1, HSPA6, IFTIM1, IL-6, IL-7, MMP-1, MMP-13 and TNFSF10 that were previously identified following microarray analysis. Human Fibroblast-like Synoviocytes isolated from RA patients (HFLS-RA) were treated with the IC50 (inhibitory concentration) of the compounds and subjected to …
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SENSITIZATION OF HUMAN OSTEOSARCOMA CELL LINE 143B WITH CALCITRIOL FOR CISPLATIN THERAPY
… lines, and the role of matrix metalloproteins (MMPs) in migration/invasion. Design: Previous findings in our lab suggests, calcitriol act as differentiation agent in human osteosarcoma cell lines 143B and SaOS-2. The dose response of cisplatin with and without calcitriol (100nM) pretreatment was …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… Metalloproteinases (Matrix metalloproteinases, MMPs and a disintegrin and metalloproteinase domain with thrombospondin motifs, ADAMTSs) play an important role in cartilage degradation. The collagenases (MMP-1 and MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5) are implicated in the development …
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Smoking and High-Fat Diet: Risk Factors Regulating Emphysema Formation
… demonstrate that matrix metalloproteinase-1 (MMP-1) likely plays a key role in the pathological degradation of the lung extracellular matrix. Together, the studies presented in this thesis indicate that, in addition to cigarette smoking, hypercholesterolemia may be an important risk factor in …
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Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification
… for similar activity. Matrix metalloproteinase (MMP) -1 and -8 were identified as viable candidates and tested for their ability to degrade collagen and enhance diffusion in tumors. When overexpressed in tumors, neither MMP significantly altered collagen content or diffusive transport. However, …
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Elucidation of the Proteases Responsible for and the Form of Soluble, Monomeric EphrinA1 Released From Cancer Cells
… here that multiple matrix metalloproteases (MMPs) are able to cleave ephrinA1, most notably MMP-1, -2, -9, and -13. The proteolytic cleavage that releases ephrinA1 occurs at three positions within the C-terminus, ending in amino acids valine-175, histidine-177, and serine-178. Moreover, …
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The role of relaxin in the regulation of human liver and kidney fibrosis
… in ?-SMA, TIMP-1 and TGF-? with increases in<br/>MMP-1 and MMP-2, consistent with H2-relaxin having potentially therapeutic<br/>antifibrotic effects by increasing the fibrolytic phenotype. In addition through<br/>the use of gel contraction assays I demonstrate that H2-relaxin reduces serum …
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Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy
… in other treatments. Matrix metalloproteinase (MMP)-1 and MMP-3 mRNA by real-time PCR significantly increased in PDT group compared with control group showing a maximal increase 24 h following PDT. TGF-β mRNA increased in PDT group at 6, 12 h post-PDT. Collagen Iα1 mRNA levels also increased …
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