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Showing 1 to 20 of 40 for “"MMP-1"”.
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Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas
… in normal brain, matrix metalloproteinase-1 (MMP-1) has been shown to be present in gliomas, and in particular in glioblastoma multiforme (GBM). To begin to examine the role of MMP-1 in these tumore, two human glioma cell lines were stably transfected with MMP-1 cDNA. Confirmation of MMP-1 …
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Regulation of Matrix Metallopeptidase-1 in Breast Cancer Metastasis
Matrix Metallopeptidase 1 (MMP-1) expression has repeatedly been correlated to tumorigenesis and metastasis. Yet, MMP-1 regulation in a metastatic context remains largely unknown. Here we confirm differential MMP-1 expression in mammary carcinoma cells with varied metastatic potentials and identify …
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The Influence of a Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter on Glioma Biology
… include the matrix metalloproteinase family. MMP-1 is a member of this family which has been well studied in many types of invasive tumors, with gliomas being an exception. We studied a single nucleotide polymorphism (SNP) in the MMP-1 promoter that may influence glioma biology. This SNP …
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Investigation of the host-mediated proteolytic response to pulmonary Mycobacterium Avium Complex infection
… by host-derived matrix metalloproteinases (MMPs). Unlike Mycobacterium tuberculosis (MTb) infection, the mechanisms of tissue destruction during MAC infection are not well-characterised. Here, I aim to elucidate if MMPs are upregulated during MAC infection, and how MMP upregulation is …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… tb). Upregulation of matrix metalloproteases (MMPs) has been documented in patients with tuberculosis (TB), while their tissue inhibitor (TIMPs) levels remained the same. Animals which can develop cavities have well-conserved MMP-1 orthologs suggesting a pivotal role of MMP-1 in cavitation. The …
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Der Einfluß von Zytokinen und Zell-Zell-Kontakten auf die Expression von Matrix-Metalloproteinasen beim multiplen Myelom
… cells. The family of matrix metalloproteinases (MMPs) and its specific inhibitors (TIMPs) represent a group of proteases that can degrade collagenous as well as non-collagenous extracellular matrix. Their expression is elevated in several tumor entities, and their influence on tumor progression …
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Extracellular Matrix Metalloproteinase Inducer (Emmprin) Regulates Matrix Metalloproteinases in Human and Baboon Uterine Endometrium
… cells secreted a full-length functional form of EMMPRIN that stimulated stromal expression of MMP-1,-2 and -3 but not EMMPRIN. We also found that endogenous stromal cell expression of EMMPRIN was important but not required for MMP stimulation.
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Clinical, biochemical and morphological aspects of cervical ripening in the first trimester
… by ELISA (IL-8) and immunohistochemistry (IHC) (MMP-1, MMP-9). In Study IV biopsies were obtained from nulliparous women suffering symptomatic or silent miscarriage and from women undergoing surgical termination of pregnancy. Morphology was studied by EM and inflammatory parameters by ELISA …
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Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα
… παραγωγή διαμεσολαβητών, όπως η IL-6 η MMP-1, η MMP-3 το κολλαγόνο τύπου-Ι και ο TIMP-1, που εμπλέκονται στη παθογένεια του ρινικού πολύποδα (ΡΠ). Ο MIF ανιχνεύθηκε στο μέσο καλλιέργειας όλων των ιστών και σε όλα τα εκχυλίσματα. Η έκφρασή του ήταν αυξημένη στον ρινικό πολύποδα σε σχέση …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
… for TGF-β1-induced matrix metalloproteinase (MMP)-1 expression, the most characterised MMP in wound healing, suggesting that TREM-2 may be required for the beneficial effects of TGF-β1 on wound healing by regulating MMP-1. An in vitro model of ischemia in stroke was then established to study …
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MMP's, TIMP's, PIIINP und Hyaluronan im Serum und Gewebe von Patientinnen mit Kapselfibrose nach alloplastischer Mammaaugmentation
Matrix metalloproteinases (MMPs) and their inhibitors, tissue-inhibitors of metalloproteinases, TIMPs, are in a physiological balance and part of the engineering of the extracellular matrix. Is this system disturbed an imbalance results and therefore fibrotic processes concerning liver fibrosis and …
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Documentation, anti-aging activities and phytochemical profiling of selected medicinal plants used by Jakun women in Kampung Peta, Mersing, Johor
… which are matrix metalloproteinase-1 (MMP-1) inhibition, elastase inhibition, tyrosinase inhibition, acetyl- and butyrylcholinesterase inhibition assays. Single formulation of U. micrantha showed the highest inhibition towards MMP-1 (49.44 ± 4.11 %) and elastase enzymes (20.33±2.52%), …
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Enzymimmunologische und immunhistochemische Untersuchungen zum Einfluss von Matrix-Metalloproteinasen und ihrer Inhibitoren auf die Entstehung der Dupuytren'schen Kontraktur
… liver, and skin, matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important role. In this study, serum concentrations of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined in 21 patients (five women and 17 men; …
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Analyse der funktionellen Bedeutung von Sequenzveränderungen ausgewählter Matrixmetalloproteinasen für die Pathogenese von Dissektionen hirnversorgender Arterien
… the skin of patients. Matrix metalloproteinases (MMP) play a central role in the regulation of the ECM particularly in the regulation of the collagens. In the vessel wall of patients with CAD a lack of kollagen III was found but neither the kollagen itself nor expression of kollagen was modified. …
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Auswirkungen der maternalen HIV-1-Infektion auf die Genexpression endothelialer Vorläuferzellen und differenzierter Endothelzellen nicht-infizierter Kinder
… die Expression von Matrix-Metalloprotease-1 (MMP-1) unter der Nachweisgrenze liegt oder signifikant reduziert ist. Dies konnte auf RNA- und Proteinebene sowie mittels Gelatine-Zymografie bestätigt werden.
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Lipoteichoic acid from Staphylococcus aureus induced expression of MMP-9 in human middle ear epithelial cells
Change in matrix metalloproteinases (MMPs) and regulation of their tissue inhibitors of metalloproteinases (TIMPs) could play certain role in the pathogenesis of otitis media. This study was designed to evaluate the modulation of MMPs and TIMPs in middle ear epithelium by lipoteichoic acid (LTA) …
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Untersuchungen zur extrazellulären Matrix unter Implantation differenter Netzmaterialien zum Bauchwandersatz
… of collagen type -I/-III ratio, expression of MMP’s), it was the frame of this study to examine, which changes could be observed during mesh implantation in the extra cellular matrix without patient depending influences in a standardised animal study. Meshes of different materials, poresize und …
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The Possible Role for Basigin Receptor Function in The Induction of Matrix Metalloproteinase Expression in Human Endometrial Stromal Cells
… Basigin has been shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help researchers understand how these signaling cascades flow in the framework …
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