Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MMP inhibition"”.
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Membrane-bound Matrix Metalloproteinases Influence Reactive Synaptogenesis Following Traumatic Brain Injury
… process influenced by matrix metalloproteinases (MMP) and their substrates. Here we report results of studies examining the expression and potential role of two membrane-bound MMPs, membrane-type 5-MMP (MT5-MMP) and a disintegrin and metalloproteinase-10 (ADAM-10), along with their common synaptic …
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Chemical biology of matrix metalloproteases
Matrix Metalloproteases (MMP) inhibition is currently brought to the focus of medicinal chemistry research due to their essential roles in many human diseases. To elucidate the functions of each individual MMP, it is imperative to synthesise small molecule/probes which can selectively target a …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
… this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of equine MMPs and evaluation of the effectiveness of MMPIs in the horse are needed. Equine MMP-9 was harvested from …
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Elucidating The Role of Cd44 Expression On Mesenchymal Stem Cells Within The Tumor Microenvironment
… of CD44-deficient MSC within the tumor stroma. Inhibition of MSC migration was evaluated through a variety of methods in vitro and in vivo including CD44 receptor knockdown, CD44 antagonists, CD44 neutralizing antibodies and small molecule inhibitor of matrix metalloproteinases. Blocking CD44 …
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TIMP-1: Zelluläre Funktion und Beeinflussung der Genexpression von Matrix-Metalloproteinasen in humanen Hepatomzellen
… pathways are involved in the regulation of MMP2 and MMP9 gens as well as how they are influenced by TIMP-1. For this purpose both certain kinases as well as their phosphorylated form (STAT 1, P-STAT 1, STAT 3, P-STAT-3, JAK 1, P-JAK 1, JAK 2, P-JAK 2, Ras GAP and JNK 1) were investigated by …
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Morphogenesis of the early post-implantation mouse embryo
… the expression of matrix metalloproteinases (MMPs) in the epiblast under the control of Nodal. The anterior visceral endoderm inhibits Nodal signalling and hence MMP inhibition in the anterior. I demonstrate that activity of the MMPs and perforations in the basement membrane are essential for …
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Experimental Colonic Obstruction and Anastomotic Healing
… carries a high risk of leakage. The effect of a MMP inhibitor was investigated but was, contrary to expected, found to deteriorate the anastomoses. On the other hand, if an inhibitor could be delivered locally, improved healing could possibly be expected without unwanted effects, since breaking …