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Showing 1 to 20 of 21 for “"MMP expression"”.
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Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
… study we examine the pre- and post-translational expression of type I collagen and MMPs -2, -3, and -9 in wildtype, heterozygous and Col1a2-deficient glomeruli to determine whether the pathogenic collagen is homotrimeric in nature, and whether alterations in MMP expression play a role in disease …
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Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases capable of digesting the extracellular matrix (ECM), which is essential for tissue structure and transmitting messages between cells. MMPs play an important role in cancer, controlling cell migration, proliferation, apoptosis, …
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Der Einfluß von Zytokinen und Zell-Zell-Kontakten auf die Expression von Matrix-Metalloproteinasen beim multiplen Myelom
… cells. The family of matrix metalloproteinases (MMPs) and its specific inhibitors (TIMPs) represent a group of proteases that can degrade collagenous as well as non-collagenous extracellular matrix. Their expression is elevated in several tumor entities, and their influence on tumor progression …
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Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
Membrane type-1 matrix metalloproteinase (MT1-MMP) is a metalloproteinase which becomes upregulated in prostate cancer and has been implicated in processes of prostate cancer metastasis. Here, we show that MT1-MMP is minimally expressed in nonmalignant primary prostate cells, moderately expressed …
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The Overexpression of Basigin-3 in Glioblastoma
… the disease. The protein Basigin-2 (aka EMMPRIN) induces the expression of matrix metalloproteinase (MMP) enzymes, and its expression level is positively correlated with GBM tumor grade. In 2011, Liao et al. reported that a splice variant of the basigin gene, called Basigin-3, may have an …
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Die Expression von Matrix-Metalloproteasen in humanen Medulloblastomen
… mit dem Vorkommen in Glioblastomen mehr über die MMP-Expression und -verteilung im MDB zu erfahren. Die Analyse erfolgte mittels PCR auf RNA-Ebene und über immunhistochemische Färbungen sowie Zymografie auf Proteinebene.
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Membrane-bound Matrix Metalloproteinases Influence Reactive Synaptogenesis Following Traumatic Brain Injury
… process influenced by matrix metalloproteinases (MMP) and their substrates. Here we report results of studies examining the expression and potential role of two membrane-bound MMPs, membrane-type 5-MMP (MT5-MMP) and a disintegrin and metalloproteinase-10 (ADAM-10), along with their common synaptic …
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The Cytoplasmic Domain of Membrane-type 1 Matrix Metalloproteinase is Required for its Survival-Promoting, but not its Migration-Promoting Function in MCF-7 Breast Cancer Cells
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a multifunctional protease that degrades proteins during cell migration, and influences cell survival. Both the protein localization and signal transduction capabilities of MT1-MMP depend on its cytoplasmic domain (CD), indicative of a diverse …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
… via stimulation of matrix metalloproteinase (MMP) expression in surrounding normal tissues, resulting in the degradation of the extracellular matrix (ECM) surrounding tumors, promoting remodeling of the tumor borders, stimulating growth. In work by Belton et al. (2008), human uterine …
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Astaxanthin Decreases Invasion and MMP Activity in Triple Negative Breast Cancer Cells
… treated with Astaxanthin demonstrate decreased MMP-2, -9, and -13 activities. Western blot analysis of conditioned media and lysates suggests that decreased MMP activity results from decreased protein expression. Using a broad-spectrum MMP inhibitor we observed a decrease in invasion of 4T1 …
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Met Inactivation by S-allylcysteine Suppresses Migration and Invasion of Nasopharyngeal Cancer Cells Induced by hepatocyte growth factor
… the reduction of matrix metalloproteinase (MMP) and Slug protein expression, and inhibition of the production of reactive oxygen species (ROS). Furthermore, evidence is emerging that shows that ROS induced by radiation could increase Met activation. Following on these reports of SAC and Met, …
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The Possible Role for Basigin Receptor Function in The Induction of Matrix Metalloproteinase Expression in Human Endometrial Stromal Cells
… process. Basigin is best known for inducing the expression of matrix metalloproteinases. Basigin has been shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help …
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Epigenetische Beeinflussung der Proliferation, Expression von Matrix-Metalloproteinasen, Migration und Invasion von Harnblasenkarzinomzelllinien
… allen Zelllinien eine unterschiedlich hohe mRNA-Expression von Matrix-Metalloproteinasen, aber auch ihrer spezifischen Inhibitoren, d) in allen Zelllinien mit Ausnahme von RT-4 eine Suppression der MMP-14-mRNA-Expression. Die mRNA-Expression und zelluläre Proteinexpression zeigten für die …
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The effects of biophysical and biochemical cues on tendon cells: a study of underlying mechanisms in tendinopathy
… were cultured on these and morphology and gene expression was assayed. Polydimethylsiloxane (PDMS) substrates mimicking healthy and tendinopathic stiffness was prepared. hTDCs viability, and hTDC and THP-1 macrophage gene expression were characterised. Rat-TDC (rTDC) were treated with palmitic …
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Expression of Epidermal Growth Factor Receptor in hypopharyngeal cancer and Effect of EGF in Progression of hypopharyngeal cancer
… (erbB3), and HER4 (erbB4). High levels of EGFR expression are correlated with poor prognosis and resistance to radiation therapy in a variety of cancers, mostly in head and neck squamous cell carcinoma (HNSCC). So we examined the expression of EGFR in hypopharyngeal cancer and the effect of EGF …
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The Role of IL-6 in Inflammatory Aortic Aneurysmal Diseases
… that is associated with reduced levels of local MMPs. These findings suggests the activation of IL-6-mediated inflammatory signaling contributed to aneurysmal progression in MFS through recruitment of leukocytes and stimulation of MMP expression, thus aggravating ECM degradation and vascular …
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Analyse der funktionellen Bedeutung von Sequenzveränderungen ausgewählter Matrixmetalloproteinasen für die Pathogenese von Dissektionen hirnversorgender Arterien
… the skin of patients. Matrix metalloproteinases (MMP) play a central role in the regulation of the ECM particularly in the regulation of the collagens. In the vessel wall of patients with CAD a lack of kollagen III was found but neither the kollagen itself nor expression of kollagen was modified. …
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Tumor microenvironmental control of metastasis : effects of the immune cells and physical forces on cell migration
… migration speed and persistence in 3D ECM in an MMP-dependent fashion via two distinct pathways. Specifically, macrophagereleased TGF1 enhances cancer cell migration speed via the induction of MTl-MMP expression in cancer cells. In contrast, macrophage-released TNFa and TGFp1 synergistically …
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Characterization and Functional Analysis of a Newly Identified Human MT5-MMP Transcript Variant Isolated from Multipotent NT2 Cells
Membrane-type 5 matrix metalloproteinase (MT5-MMP) is unique among MMP family members as it is predominately expressed in the CNS. Its expression is ubiquitous during brain development and restricted to regions of neurogenesis and neuroplasticity in the adult. MT5-MMP is a mediator of pericellular …
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Nuclear and Molecular Imaging Modalities for Predicting Calcific Aortic Valve Disease Progression in Animal Models
… Namely, one target of particular interest is the expression of matrix metalloproteinases (MMPs) (specifically MMP-1, -2, and -9) which are upregulated in CAVD prior to calcification events and have been previously shown to serve as an attractive molecular imaging target.1–3 The primary objective …
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