Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"MMP 9"”.
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MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
<p>Matrix metalloproteinase-9 (MMP-9) is a 92 kDa zinc-dependant endopeptidase that degrades components of the extracellular matrix. Enhanced expression of MMP-9 has been implicated in many pathological conditions including cancer metastasis, multiple sclerosis, and atherosclerosis. Although it has …
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Lipoteichoic acid from Staphylococcus aureus induced expression of MMP-9 in human middle ear epithelial cells
Change in matrix metalloproteinases (MMPs) and regulation of their tissue inhibitors of metalloproteinases (TIMPs) could play certain role in the pathogenesis of otitis media. This study was designed to evaluate the modulation of MMPs and TIMPs in middle ear epithelium by lipoteichoic acid (LTA) …
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… severe side effects. Matrix metalloproteinases (MMPs) represent the most prominent family of endopeptidases that are necessary for normal growth and development but are also involved in the disruption of the blood-brain barrier (BBB), neuronal cell death, neuroinflammation and/or …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
… this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of equine MMPs and evaluation of the effectiveness of MMPIs in the horse are needed. Equine MMP-9 was harvested from …
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
… the activity of the matrix metalloproteinases-9 (MMP-9) that are involved in the enzymatic remodelling of the extracellular matrix. MMP-9 regulates the degradation of extracellular matrix in processes such as angiogenesis, tumour growth, and metastasis. By forming the NGAL/MMP-9 complex, NGAL …
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Coronary Artery Outcome in Kawasaki Disease: The Role of Matrix Metalloproteinase-9 and Therapeutic Modulation of Its Activity
… of the elastase, matrix metalloproteinase (MMP)-9. MMP-9 protein and activity levels were elevated in the heart post-disease induction. Expression and activity were specific for and localized to inflamed coronary arteries. The pro-inflammatory cytokine, tumour necrosis factor (TNF)-α, was …
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The Expression of Matrix Metalloproteinase-9 and -2 in Olfactory Injury and Recovery
… remain unknown. The matrix metalloproteinases (MMPs) are important components in many central nervous system (CNS) injury paradigms, yet remain unexplored in olfactory injury and recovery. To address the role of MMPs, the temporal expressions of MMP-9 and MMP-2 were examined in 3 olfactory …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… tb). Upregulation of matrix metalloproteases (MMPs) has been documented in patients with tuberculosis (TB), while their tissue inhibitor (TIMPs) levels remained the same. Animals which can develop cavities have well-conserved MMP-1 orthologs suggesting a pivotal role of MMP-1 in cavitation. The …
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Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… inhibitors or inhibitors of metalloproteinases (MMP) showed that only inhibition of MMP-9 specifically blocked TNFα-induced axonal proliferation. The inhibition of MMP-9 in co-cultures also blocked the increase in 15 kDa GDNF expression, while the overall expression of GDNF was not affected. …
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Visualizing the Spatial Localization of Active Matrix Metalloproteinases (MMPs) using MALDI Imaging MS
… chemokines, and matrix metalloproteinases (MMPs). The nature of the FBR requires the spatial and temporal regulation of these mediators. MMPs are an extremely large and diverse group of enzymes that play key roles in regulating the FBR. Precise spatiotemporal regulation of MMPs defines their …
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The Treatment of Breast Cancer Tumor Growth and Metastasis With an Anti-MMP9 DNAzyme
… basement membrane by neutral metalloproteinases (MMP) produced by tumor and stromal cells. MMP-9 is known to play a significant role in breast tumor cell invasion and metastasis via degradation of ECM components and activation of cytokines and chemokines. MMP-9 is known to cleave type IV collagen, …
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Analysis of biological pathways, associated with orthodontic force, using multiplex arrays
… IL-4, IL-5, IL-6, IL-8, IL-10, TNF), tissue (MMP-9, TIMP-1 and 2) and bone metabolism (RANKL, OPG) biomarkers were measured. Results –IL-1β, IL-8, TNFα, MMP-9 increased in canine tension sites and TIMPs 1 and 2 from T2-T4, canine compression sites showed increases in IL-1β and IL-8 only at T2, …
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Antiinflammatorische Wirkungen und Pharmakokinetik eines standardisierten Kiefernrindenextraktes
… Substrate vor enzymatischer Degradierung durch MMPs infolge einer Adsorption der Procyanidine abgeleitet. Die Metabolite M1 und M2 schienen auf Grund eines anderen Mechanismus die Aktivität der MMPs zu hemmen. Es konnte gezeigt werden, dass die Hemmwirkung der untersuchten Inhibitoren auf MMP-9 …
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Effect of Methamphetamine on Gingival Fibroblast Production of Matrix Metalloproteinase (MMP)-2 and -9 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 and -2 In Vitro
… and periodontitis. Matrix metalloproteinases (MMPs) produced by gingival fibroblasts degrade the extracellular matrix (ECM) and play an important role in periodontitis and oral cancer metastasis. There is no information on effects of METH on fibroblast MMP production, or its role in …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… molecule VCAM-1 and matrix metalloproteinases MMP-2 and 9 at peak of EAE in treated mice. The decrease in VCAM-1 correlates with our previous observation of decreased leukocyte rolling and adhesion to brain microvasculature. However, the reduction in MMP-2/9 expression suggests that CB2R …
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Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
… of GFs. However, matrix metalloproteinase-9 (MMP-9) secretion was inhibited by heating, with more significant declines associates with GF inclusion. Equibiaxial tension (5%, 0.2 Hz, 10 seconds tension/10 seconds rest, 6 days) with GFs enhanced proliferation than tension or GF addition alone. …
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Effects of systemic flunixin meglumine, topical oxytetracycline, and topical prednisolone acetate on tear film proteinases innormal horses
… of two proteinases, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), in equine tear film. The study design consisted of twelve ophthalmically normal horses separated into three groups of four in a cross-over study design. Each group was treated for 5 days with flunixin …
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The role of genetic factors in breast cancer aetiology
… gene and matrix metalloproteinase-9 gene (MMP-9) with grade and presence<br/>of distant metastasis respectively.<br/><br/>The function of two promoter SNPs in MMP-9 were further investigated using luciferase reporter<br/>gene assays. The C allele of rs3918242 had a 1.5 fold increase in …
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Valutazione dell'attività delle metalloproteinasi 2 e 9 nelle urine e nel tessuto renale di cani normali e affetti da nefropatia
Matrix metalloproteinases (MMP) are a large family of proteinases that remodel extracellular matrix (ECM) component. Recent data suggest a role for MMPs in a number of renal pathophysiologies, associated with an imbalance of ECM syntesis and degradation, which may result in an accumulation of ECM …
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Identification of Transmembrane and Extracellular Host Proteases that Promote Human CoV Entry and Syncytium Formation
… evidence implicating matrix metalloproteinase-9 (MMP-9) as a fusion trigger for SARS-CoV-2 and HCoV-229E. Additionally, I show MMP-9 expression is upregulated during CoV infection, highlighting its potential relevance as a CoV triggering factor.
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