Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"MMAE"”.
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Electrochemical Model Based Fault Diagnosis of Lithium Ion Battery
… namely multiple model adaptive estimation (MMAE) method, was implemented for this purpose. In this estimation algorithm, all the identified models were simulated for a battery current input profile extracted from the hybrid pulse power characterization (HPPC) cycle simulation of a hybrid …
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Developing Zebrafish as an In Vivo Model to Screen Compounds for Anti-Cancer Activity in Human Breast Cancer
… ansamitocin P-3, and monomethyl auristatin E (MMAE). NOAELs for paclitaxel, mertansine, ansamitocin P-3, and MMAE were 25, 400, 50, and 400 nM, respectively. Zebrafish were xenotransplanted with MCF-7, BT-474, and MDA-MB-231 cell lines to observe the effects of exposure to microtubule …
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Fault-Tolerant Control of Unmanned Underwater Vehicles
… using the multiple-model adaptive estimation (MMAE). The algorithm activates latter levels only when the failure is detected, and can return back to the monitoring loop in case of false failures. On the basis of MMAE, we use multiple sliding-mode controllers and reconfigure the control law with …
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Development and characterization of anti-EGFR protein-drug conjugates for tumor therapy
… Fc domain (__DFc__). Monomethyl auristatin E (MMAE)-conjugates of __DD1__ (DAR = 2.0) and __DFc__ (DAR = 4.0) revealed sub-nanomolar cytotoxicity against EGFR-overexpressing A431 cells. Confocal fluorescence microscopy of corresponding fluorescent dye derivatives showed receptor-mediated …
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Proteinkonjugationen durch Kupfer-abhängige Formylglycin-generierende Enzyme zur Generierung von Antikörper-Wirkstoff-Konjugaten
… was loaded with monomethyl auri-statin E (MMAE) and carboxyfluorescein. In the cell-based methods live cell imaging and ala-marBlue® assay a direct correlation between the presentation of the EGFR on the cell surface and the ADC-dependent fluorescence or cytotoxicity was demonstrated, …
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Identifying potential binding sites of Nectin 4 for bespoke anti-cancer peptides
… synthetic cyclic peptides conjugated to an MMAE (Monomethyl auristatin E) toxin, which have significantly reduced toxicity issues compared to those typically associated with conventional antibody drug conjugates. This is due to their unique design, size and excretion pathway. The precise …
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Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… with different toxins (monomethyl auristatin E (MMAE) and a pyrrolobenzodiazepine dimer (SG3199)) as payload and a bispecific antibody targeting L1CAM on tumor cells and CD3 on T cells in different preclinical PDAC models. Both L1CAM-ADC led to a L1CAM specific reduction in tumor cell growth of …
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Designed Bond Cleavage Reactions for Next-Generation Therapeutics
… agents such as monomethyl auristatin E (MMAE) from antibody-drug conjugates (ADCs). The efficacy of this approach was also evaluated in a colorectal zebrafish xenograft model, offering promising insights into the application of Au complexes beyond those in catalysis to bond-cleavage …
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Single-Payload Bioconjugation to Native Antibodies And A General Method for the Self-Immolative Release of Amide-Containing Molecules
… creation of protein catcher SpyTag, cytotoxic MMAE, and fluorophore BODIPY single-payload conjugates of trastuzumab. Flow cytometry and SpyTag-SpyCatcher studies carried out by Claudia Driscoll, Howarth group, showed that the ‘all-at-once’ TetraDVP concept can be used to make single-payload …