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Synthesis, Screening and Cocrystallization of Adenosine Based Inhibitors with Methyltransferases, ErmC' and KsgA

Baker, Matthew2016

<p>Antibiotic resistance threatens to throw mankind back into an era when infectious disease was the predominant cause of death. In an effort to mitigate this danger, we targeted ErmC’ and KsgA. Both methylate N6-adenosine of ribosomal RNA, though each serve different roles in their bacterial host. …

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