Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"MLL2"”.
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Critical Functions Specified by the MLL CXXC Domain Determine Leukemogenic Capacity
… of a fusion partner. The closest homolog of MLL, MLL2 (alternatively named MLL4), also contains a similar CXXC domain, yet an artificial MLL2 fusion protein is unable to transform cellsin vitro. I hypothesized that specific amino acid differences between the MLL and MLL2 CXXC domains account for …
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Interplay Between P53 and Epigenetic Pathways in Cancer
… bind to and upregulate genes including MLL1, MLL2, and MOZ, leading to genome-wide changes of histone modifications. These studies also demonstrate a critical functional role of the MLL pathway in mediating mutant p53 GOF cancer phenotypes, and that genetic or pharmacological perturbation of …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… (MED12) and the lysine methyltransferase KMT2D/MLL2. Both of these proteins are implicated in enhancer function. We identified the primary CARM1-mediated MED12 methylation site as arginine 1899. Using methyl-specific antibodies to this site, we found that MED12 methylation positively correlates …
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Developmental Characterization of Cara Mitad: A Drosophila Nuclear Receptor Co-Regulator
<p>In insects and vertebrates, hormone titers drive cellular proliferation and differentiation events that guide proper development. Nuclear receptors (NR) respond to these hormone signals by activating cascades of gene expression, along with coregulator protein complexes. In Drosophila …