Global ETD Search
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Showing 1 to 8 of 8 for “"MLL-fusion"”.
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The Specific Role of the MLL CXXC Domain in MLL Fusion Protein Function
<p>The MLL gene was first identified because it is involved in chromosome translocations which produce novel fusion proteins that cause leukemia. The CXXC domain of MLL is a cysteine rich DNA binding domain with specificity for binding unmethylated CpG-containing DNA. The CXXC domain is retained in …
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Mechanistic Insights into Direct Interactions that Mediate the Activity of DOT1L Complex in MLL-Rearranged Leukemia
… can arise from the translocation-mediated fusion of the N terminus of the Mixed Lineage Leukemia (MLL) protein to various partner proteins. Although more than 60 different translocation-based fusion proteins have been identified, fusion partners such as AF9, AF10, and ENL constitute the …
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The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
… by the translocation of Mixed-lineage leukemia (MLL) gene. Mice transplantation with KAT7 knock-out AML cell line showed delayed disease progression and prolonged survival compared to those injected with the wild-type counterpart. The acetyltransferase activity of KAT7 is essential for MLL-fusion …
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A Study of the Therapeutic Potential of AF4 Mimetic Peptides
<p>Mixed lineage leukemias (MLL) are a group of acute and aggressive leukemias. They account for over 70% of infant leukemias, and 10% of acute adult leukemias. Pediatric ALL and therapy related MLL leukemias carry poor prognosis in spite of several advancement in the field of leukemia research. …
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Critical Functions Specified by the MLL CXXC Domain Determine Leukemogenic Capacity
<p>TheMixed Lineage Leukemia(MLL) gene can participate in chromosomal translocations which generate a fusion protein leading to acute leukemia. A better understanding of how MLL fusion proteins contribute to leukemia is necessary in order to develop more effective treatments. In my dissertation …
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Significance of Protein Interactions in Mediating AF9 Function
<p>Rearrangements of the MLL gene at chromosome band 11q23 have been associated with a heterogeneous group of lymphoid, myeloid and mixed lineage leukemias. MLL rearrangements occur approximately in 70% of infant leukemias and are also common in therapy-related leukemias where patients were …
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The Role of Cyp33 in MLL Mediated Gene Repression
<p>Mixed Lineage Leukemia (MLL) is a multidomain protein whose gene is translocated in a subset of AML leukemias. Translocation of the MLL gene is present in approximately five percent of adult acute leukemias and ten percent of pediatric leukemias (Daser, A 2004, Look, A 1997, Huret, J 2001) …
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Trim24 In Normal & Malignant Hematopoiesis
… loss of <em>Trim24</em> in murine, <em>MLL</em>-<em>AF9</em>-driven AML worsened survival and increased leukemic stem cell numbers, while having no observed effects on normal hematopoiesis. These results lay the groundwork for future investigations of the role of <em>TRIM24</em> in AML, …