Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"MLL-Gene"”.
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Topology of Genes in Mammalian Cell Nuclei with Special Emphasis on the MLL Gene and Its Translocation Partners
… double strand break event, chromosomes are fused generating derivative chromosomes. During the fusion, a chimeric gene can be created and a fusion protein with new functions may be expressed which might cause malignant transformation. One such gene is MLL, which can be fused to a large number of …
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Treatment Outcomes in Children with Very High Risk Acute Lymphoblastic Leukemia Intended to Treat with Allogeneic Hematopoietic Stem Cell Transplantation
… lymphoblastic leukemia (VHR ALL) in childhood is generally poor in spite of intensive chemotherapy. Recently, allogeneic hematopoietic stem cell transplantation (Allo-HSCT) was use to treat the patients with VHR ALL. We studied the clinical course and outcomes of children with VHR ALL intended …
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The Role of Cyp33 in MLL Mediated Gene Repression
<p>Mixed Lineage Leukemia (MLL) is a multidomain protein whose gene is translocated in a subset of AML leukemias. Translocation of the MLL gene is present in approximately five percent of adult acute leukemias and ten percent of pediatric leukemias (Daser, A 2004, Look, A 1997, Huret, J 2001) …
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The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
… KAT7 as an AML-specific cell-essential gene and therefore may represent a potential novel therapeutic target for AML. Here, I show that KAT7 loss leads to a rapid and dramatic global reduction in both H3K14ac and H4K12ac in association with reduced proliferation, increased apoptosis or …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… disease caused by both inherited and acquired genetic alterations. Current AML classification and prognostic systems incorporate genetic information but are limited to known abnormalities that have previously been identified with the use of cytogenetics, array comparative genomic hybridization …
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Characterization of chromosomal abnormalities in acute myeloid leukaemia patients at the university teaching hospital, Lusaka, Zambia
… disease caused by both inherited and acquired genetic alterations. Current AML classification and prognostic systems incorporate genetic information but are limited to known abnormalities that have previously been identified with the use of cytogenetics, array comparative genomic hybridization …
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Anc1 : a new player in the cellular response to DNA damage
… mechanisms to avoid and repair damage to their genetic material. In this thesis, we analyze a yeast gene that has a previously uncharacterized role in the cell's ability to survive after DNA damage. This gene, ANC1, is interesting for several reasons. First, ANC1 is the only common member of …
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Significance of Protein Interactions in Mediating AF9 Function
<p>Rearrangements of the MLL gene at chromosome band 11q23 have been associated with a heterogeneous group of lymphoid, myeloid and mixed lineage leukemias. MLL rearrangements occur approximately in 70% of infant leukemias and are also common in therapy-related leukemias where patients were …
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
… role of S6K1 in hematopoiesis as well as leukemogenesis, we used a genetic model of S6K1 deficient mice (S6K1-/-). We found that loss of S6K1 expression in HSCs results in reduction of absolute HSC number in bone marrow (BM). Following chemotherapy, cycling HSCs undergo apoptosis and quiescent …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… common chromosomal translocation partners of the MLL gene in MLL leukemia. Wild-type AF9 is a member of the pTEFb transcription elongation complex, and interacts with gene regulatory proteins such as AF4/AF5q31, DOT1L, Pc3/CBX8 and BCoR. These interactions are retained in the oncogenic MLL-AF9 …
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Critical Functions Specified by the MLL CXXC Domain Determine Leukemogenic Capacity
<p>TheMixed Lineage Leukemia(MLL) gene can participate in chromosomal translocations which generate a fusion protein leading to acute leukemia. A better understanding of how MLL fusion proteins contribute to leukemia is necessary in order to develop more effective treatments. In my dissertation …
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The Specific Role of the MLL CXXC Domain in MLL Fusion Protein Function
<p>The MLL gene was first identified because it is involved in chromosome translocations which produce novel fusion proteins that cause leukemia. The CXXC domain of MLL is a cysteine rich DNA binding domain with specificity for binding unmethylated CpG-containing DNA. The CXXC domain is retained in …
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A Study of the Therapeutic Potential of AF4 Mimetic Peptides
<p>Mixed lineage leukemias (MLL) are a group of acute and aggressive leukemias. They account for over 70% of infant leukemias, and 10% of acute adult leukemias. Pediatric ALL and therapy related MLL leukemias carry poor prognosis in spite of several advancement in the field of leukemia research. …
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Brüche am MLL-Gen durch apoptotische Vorgänge im Zuge von Probenalterungen im Vergleich zu Brüchen im MLL-Gen bei t-AML
Im Zuge unserer Experimente am MLL-Gen konnten wir feststellen, das Brüche am MLL-Gen nicht ausschließlich durch Exposition mit Chemo- oder Strahlentherapie entstehen, sondern auch durch andere Faktoren wie z.B. spontane Apotose durch verlängerte Lagerungszeiten möglich ist. Daher ist für wietere …