Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"MLL-ENL"”.
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Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
… activities. Among those, t(11;19) generates the MLL-ENL fusion protein, an aberrant transcriptional factor with an unusual mechanism of transcriptional activation targeting the elongation step of transcription. MLL rearrangements develop a unique category of AML and ALL, mainly affecting infants …
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From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics
… capabilities. Rearrangements involving the *MLL1* gene (*Kmt2a*) produce powerful oncogenic proteins occurring predominantly in paediatric and infant acute myeloid and lymphoid leukaemias. Despite having more than 80 fusion partners, MLL-AF9, MLL-AF4 and MLL-ENL make up more than 60% of cases …