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Showing 1 to 20 of 68 for “"MLL"”.
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The Specific Role of the MLL CXXC Domain in MLL Fusion Protein Function
<p>The MLL gene was first identified because it is involved in chromosome translocations which produce novel fusion proteins that cause leukemia. The CXXC domain of MLL is a cysteine rich DNA binding domain with specificity for binding unmethylated CpG-containing DNA. The CXXC domain is retained in …
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Mit AML assoziierte MLL-partielle Tandemduplikationen (MLL-PTD) sind in Stammzellen aus Nabelschnurblut lebenslang nachweisbar
… bei gesunden Individuen auf. AML, welche eine MLL-PTD aufweisen, haben eine schlechtere Prognose. Um die Bedeutung der MLL-PTD in der Leukämogenese zu erklären, untersuchten wir Nabelschnurblutproben von gesunden Individuen. Hierzu wählten wir die Methode der …
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Brüche am MLL-Gen durch apoptotische Vorgänge im Zuge von Probenalterungen im Vergleich zu Brüchen im MLL-Gen bei t-AML
Im Zuge unserer Experimente am MLL-Gen konnten wir feststellen, das Brüche am MLL-Gen nicht ausschließlich durch Exposition mit Chemo- oder Strahlentherapie entstehen, sondern auch durch andere Faktoren wie z.B. spontane Apotose durch verlängerte Lagerungszeiten möglich ist. Daher ist für wietere …
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The Role of Cyp33 in MLL Mediated Gene Repression
<p>Mixed Lineage Leukemia (MLL) is a multidomain protein whose gene is translocated in a subset of AML leukemias. Translocation of the MLL gene is present in approximately five percent of adult acute leukemias and ten percent of pediatric leukemias (Daser, A 2004, Look, A 1997, Huret, J 2001) …
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Characterising the MLL complex: epigenetic regulation of Hoxa genes
The Mixed-Lineage Leukaemia (MLL1) protein is a key developmental factor that acts to regulate genes via its histone methyl-transferase activity. This study aimed to examine how MLL1 and its associated complex contribute to gene regulation in a functionally relevant cell background. To assess …
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Critical Functions Specified by the MLL CXXC Domain Determine Leukemogenic Capacity
<p>TheMixed Lineage Leukemia(MLL) gene can participate in chromosomal translocations which generate a fusion protein leading to acute leukemia. A better understanding of how MLL fusion proteins contribute to leukemia is necessary in order to develop more effective treatments. In my dissertation …
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Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.
… which was developed in Vav-tTA TRE-NRASG12V ; Mll-AF9 transgenic ( TRM -transgenic) mice, into recipient SCID mice. Conditional repression of NRAS G12V expression greatly reduced peripheral white blood cell (WBC) counts in leukemia recipient mice and induced apoptosis in the transplanted AML …
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Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3
<p>Mixed Lineage Leukemia protein (MLL) is required for proper embryonic development, and hematopoiesis. It is a SET domain containing histone methyl transferase that trimethylates histone H3 on lysine 4 (H3K4Me3), a histone modification that correlates with active transcription. The 3rd PHD finger …
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Role of Non-Coding RNA NC4 in MLL and CYP33 Mediated Regulation of HOXC8
<p>MLL or Mixed Lineage Leukemia gene is clinically known for its involvement in genetic translocation with more than 70 different partners identified each giving rise to a highly leukemogenic fusion protein. With a poor prognosis of MLL related leukemia, an investigation into its role during …
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Mechanistic Insights into Direct Interactions that Mediate the Activity of DOT1L Complex in MLL-Rearranged Leukemia
… of the N terminus of the Mixed Lineage Leukemia (MLL) protein to various partner proteins. Although more than 60 different translocation-based fusion proteins have been identified, fusion partners such as AF9, AF10, and ENL constitute the majority of the MLL-rearranged leukemia cases; …
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Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
… activities. Among those, t(11;19) generates the MLL-ENL fusion protein, an aberrant transcriptional factor with an unusual mechanism of transcriptional activation targeting the elongation step of transcription. MLL rearrangements develop a unique category of AML and ALL, mainly affecting infants …
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Topology of Genes in Mammalian Cell Nuclei with Special Emphasis on the MLL Gene and Its Translocation Partners
… cause malignant transformation. One such gene is MLL, which can be fused to a large number of other genes in different types of leukemias. It is believed that the 3D localization of genes, involved in chromosomal translocations in the interphase nucleus of certain hematopoietic tissues, could be a …
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Speciation and microbial transformation of chromium, arsenic and mercury in municipal landfill leachate
… investigated in municipal landfill leachate (MLL) to evaluate microbial transformation of the heavy metals in the landfill system. MLL is a complex matrix that contains multiple inorganic and organic contaminants, as well as a consortium of bacteria in an environment of changing pH and redox …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… common chromosomal translocation partners of the MLL gene in MLL leukemia. Wild-type AF9 is a member of the pTEFb transcription elongation complex, and interacts with gene regulatory proteins such as AF4/AF5q31, DOT1L, Pc3/CBX8 and BCoR. These interactions are retained in the oncogenic MLL-AF9 …
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A Study of the Therapeutic Potential of AF4 Mimetic Peptides
<p>Mixed lineage leukemias (MLL) are a group of acute and aggressive leukemias. They account for over 70% of infant leukemias, and 10% of acute adult leukemias. Pediatric ALL and therapy related MLL leukemias carry poor prognosis in spite of several advancement in the field of leukemia research. …
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Significance of Protein Interactions in Mediating AF9 Function
<p>Rearrangements of the MLL gene at chromosome band 11q23 have been associated with a heterogeneous group of lymphoid, myeloid and mixed lineage leukemias. MLL rearrangements occur approximately in 70% of infant leukemias and are also common in therapy-related leukemias where patients were …
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The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
… by the translocation of Mixed-lineage leukemia (MLL) gene. Mice transplantation with KAT7 knock-out AML cell line showed delayed disease progression and prolonged survival compared to those injected with the wild-type counterpart. The acetyltransferase activity of KAT7 is essential for MLL-fusion …
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Microwave techniques and applications for semiconductor quantum dot mode-locked lasers
Semiconductor mode-locked lasers (MLLs) are important as compact and cost-effective sources of picosecond or sub-picosecond optical pulses with moderate peak powers. They have potential use in various fields including optical interconnects for clock distribution at an inter-chip/intra-chip level as …
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From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics
… capabilities. Rearrangements involving the *MLL1* gene (*Kmt2a*) produce powerful oncogenic proteins occurring predominantly in paediatric and infant acute myeloid and lymphoid leukaemias. Despite having more than 80 fusion partners, MLL-AF9, MLL-AF4 and MLL-ENL make up more than 60% of cases …
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