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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion

Abi Saab, Widian F.University of Toledo2013

… Here, we show that the beta form of MLK4 (MLK4beta), unlike its close relative, MLK3, and other known MAP3Ks, negatively regulates the activities of the MAPKs, p38, ERK and JNK, even in response to stimuli such as sorbitol or TNFa. MLK4beta; also negatively regulates basal, but not …

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