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Showing 1 to 2 of 2 for “"MLK3"”.
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Regulation von MAPK Signalwegen durch die Sein/Threonin Kinase MLK3
… ist. In der voliegenden Arbeit zeigen wir, dass MLK3 Cdc42/Rac induzierte JNK/SAPK Aktivität vermittelt, welches zu einer anschließenden Phosphorylierung und verstärkter transkriptioneller Aktivität des zur AP-1 Familie gehörenden immediate early Gens c-Jun führt. Zusätzlich phosphoryliert MLK3 …
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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion
… of MLK4 (MLK4beta), unlike its close relative, MLK3, and other known MAP3Ks, negatively regulates the activities of the MAPKs, p38, ERK and JNK, even in response to stimuli such as sorbitol or TNFa. MLK4beta; also negatively regulates basal, but not TNFalpha-induced, NF-kappaB activity. …