Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"MLCP"”.
-
Regulation of blood platelet function by nitric oxide
… G, prevents this inhibitory phosphorylation of MLCP by at least two mechanisms, (i) inhibiting the ROCK pathway that phosphorylates MLCP, and (ii) directly phosphorylating MLCP at an independent site, Serine⁶⁹⁵. These original observations hint at a novel mechanism for platelet regulation by the …
-
MATHEMATICAL MODELLING OF CALCIUM DEPENDENT ACTIVE CONTRACTION IN A GASTROINTESTINAL SMOOTH MUSCLE CELL
… of activation of Myosin Light Chain Phosphatase (MLCP) for rapid relaxation has been tested and modelled. Third, calcium desensitization has been modelled by describing two secondary regulatory pathways ¿ (i) enhanced activation of MLCP and (ii) down regulation of MLCK activation through its …
-
Chemical Biology Tools for Biochemical and Functional Analysis of Myosin Phosphatase
… dysregulation of myosin light chain phosphatase (MLCP), a holoenzyme composed of a catalytic subunit (PP1cβ) and a regulatory subunit that targets the phosphatase to sarcomeric substrates. PPP1R12C is an atrial-enriched MLCP regulatory subunit that directs PP1cβ to the myosin regulatory light …
-
The influence of oxidised low density lipoproteins on platelet activation
… kinase dependent inhibition of MLC phosphatase (MLCP). OxLDL induced platelet shape change correlated with MLCSer¹⁹ phosphorylation. OxLDL also stimulated a tyrosine kinase pathway involving the proteins Syk and PLCγ2, which were confirmed to be involved in MLCSer¹⁹ phosphorylation. Furthermore, …
-
Stretch-Dependant Tonic Force Maintenance in Rabbit Epigastric Artery
… of contraction. Myosin light chain phosphatase (MLCP) inhibition by RhoA Kinase (ROK) has been shown to contribute to this increased force production without simultaneous increases in calcium in a process known as Ca2+ sensitization.Epigastric artery (EA) has a unique regulatory mechanism …
-
The Non-genomic Signaling Pathways Mediated By G-protein Coupled Estrogen Receptor 1 (GPER) In Coronary Arteries
… coronary relaxation through activation of MLCP via inhibition of RhoA activity by both PKA and Epac; 5) the interaction between AKAP and PKA is involved in the cAMP/PKA signaling mediated by GPER in coronary artery; and 6) GPER potentiates coronary artery contraction via G?? signaling to …
-
Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
… kinase (ROCK), myosin light chain phosphatase (MLCP) and Src kinase, will be determined. These studies will help gain an understanding for how even binge ethanol in combination with burn injury can result in decreased barrier function that has been clinically observed and can result in increased …
-
Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… mechanisms by myosin light chain phosphatase (MLCP) inhibition is being increasingly recognized as these mechanisms have been shown to be altered in many pathological states of smooth muscle contraction. Similar to any other signaling pathways, activation of Ca2+ sensitization pathways is also …