Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"ML-SA1"”.
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… transient receptor potential mucolipin 1 (TRPML1) activates calcineurin, which dephosphorylates TFEB, promoting its nuclear translocation. In this study, we investigated the therapeutic potential of TRPML1/TFEB axis for the treatment of WD. We first assessed the effects of TFEB and TRPML1 …
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Targeting Sequence and Function-Dependence of Subcellular Localization of Transient Receptor Potential Mucolipin Channels and Characterization of Engineered Molecule Probes For Detecting Lysosomal Calcium Release
<p>Both TRPML1 and TRPML3 are members of the mucolipin subfamily of Transient Receptor Potential (TRP) channels. They have been implicated in endolysosomal functions such as divalent cation release, luminal pH regulation, autophagy and vesicle trafficking. Interestingly, whereas TRPML1 is almost …