Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"MKP-1"”.
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β-Sitosterol Isolated from Theobroma Cocoa Induces the Expression Of Mkp-1 and Il-10 In Trigeminal Neurons
… from column chromatography for expression of MKP-1 in trigeminal cultures. The active compound was identified as β-sitosterol based on NMR and HPLC/MS/MS data. The anti-inflammatory mediators MKP-1 and IL-10 were up-regulated in trigeminal neurons in a concentration-dependent manner by …
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Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity
… Mitogen-Activated Protein Kinase Phosphatases (MKPs). The MKPs are a family of eleven dual-specificity threonine-tyrosine phosphatases that attenuate MAP Kinase signaling by dephosphorylating them. </p> <p> Increased ERK signaling has been shown to correlate with poor prognosis in breast cancer …
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A Study on the Effect of Peroxisome Proliferator-Activated Receptors (PPARs) Activation in Cultured Rat Brain Glial Cells
… kinase (JNK) and MAP kinase phosphatase-1 (MKP-1), upstream molecules of them. Taken together, these results show that signaling of MCP-1 expression differ from stimulus, such as LPS and IFN-？, and their production was differentially regulated by activators of PPAR-？ and ？？, which were …
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Characterization and Reversal of Doxorubicin-Mediated Changes In Sensory Neurons
… upon a transient decrease in MAPK phosphatase-1 (MKP-1) protein, and thus reduced dephosphorylation rates, and the late phase of ERK activation depending upon delayed ERK kinase (MEK) activation. Early MEK activation also contributed to the late ERK activity, seemingly indirectly through its …
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The effect of exercise on spatial learning and hippocampal proteins in maternally separated adult rats
… mitogen-activated protein kinase phosphatase-1 (MKP-1) and brain derived neurotrophic factor (BDNF) after exercise. Cohorts 2 and 3 were trained in the Morris Water Maze (MWM) 1 and 15 days post-exercise, respectively. Consistent with our previous findings, pERK was increased in …
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D2R Dopamine Receptor Mediates Changes in Dual Specificity Phosphatase Expression in a Small Cell Lung Cancer Cell Line
… causes significant increases in DUSP‑1 (MKP‑1), DUSP‑4 (MKP‑2) and DUSP5 mRNA. NPA treatment also correlates with increases in DUSP5 (hVHR3) protein visualized using Western Blot. These three genes were also induced by treatment with exogenous arachidonic acid (AA). In addition, the NPA …
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Effect of Scutellaria Baicalensis on Reduction of Radiation/chemotherapy induced Inflammation
… Mitogen Activated Protein Kinase Phosphatase-1 (MKP-1), possibly leading to inhibiting the inflammation. Furthermore, S decreased slightly the NFκB retention within nucleus of the LPS stimulated RAW cells. There was no significant effect to reduce the inflammatory severity in both jejunum-ileum …
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Influence of the Atrial Natriuretic Peptide on TNF- αα α -activated human endothelial cells
… a significant transcriptional induction of the MKP-1 by ANP. intercellular gap5.1.3 Effect of ANP on TNF- α αα-induced MCP-1 expression The results of the third part of the present work are summerized in figure 3. figure 3 summary: schematic diagram of the signal transduction pathways clarified …
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
… of the ganglion. The MAP kinase phosphatases MKP-1, MKP-2, and MKP-3 were also found to be increased in response to NO/protons. Additionally, NO/protons facilitated movement of True Blue dye from neurons to surrounding glia, indicating increased gap junction activity. Results from my study …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
… over-expression of the MAP kinase phosphatase MKP-1 (the dual-specificity phosphatase, DUSP-1) reduced cardiac hypertrophy. Ang-(1-7) significantly increased DUSP-1 protein expression in the heart (2.64 ± 0.68, n = 6, p < 0.05) compared to animals treated with saline (0.90 ±.0.30). Co-infusion …