Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"MK2"”.
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Neue Interaktionspartner der MAPKAP-Kinasen 3pK und MK2
… (MAPKAP-Kinasen), 3pK und MAPKAP-K2 (MK2), wurden Mitglieder eines Säuger-Polycomb-Komplexes, HPH2 und das Protoonkoprotein Bmi1, als Interaktionspartner identifiziert. Proteine aus der Polycomb-Gruppe (PcG) sind dafür bekannt, multimere, Chromatin-assoziierte Proteinkomplexe zu …
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The role of MK2/TTP pathway in regulating early development and innate immunity in zebrafish
… protein kinase 2a (mapkapk2a), also known as mk2a. One of the downstream targets of MK2a is an RNA binding protein Tristetraprolin (TTP). bbp mutants lose the expression of YSL specific genes mxtx1 and mxtx2. Here, we show that these genes are regulated through their 3’untranslated region …
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Genetic and Chemical Genetic Approaches to Shiga Toxin Inhibition
… protein kinase-activated protein kinase 2: MK2) as a kinase involved in the host stress response to Shiga toxin. MK2 was activated following ribotoxic stress and contributed to the Shiga toxin-induced acute inflammatory response. Genetic and chemical inhibition of MK2 significantly reduced …
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The Effects Of Mercuric Chloride On Cultured Atlantic Spotted Dolphin (Stenella Plagiodon) Renal Cells And The Role Of Selenium In Protection
… status of Sp1K and Rhesus monkey renal cells (MK2), and (3) of sodium selenite (Na₂SeO₃) on cell proliferation and cell death of control and HgCl₂-treated Sp1K cells. HgCl₂ affected multiple organelles and nuclei in Sp1K cells, and induced apoptosis in a time-and dose-dependent manner. Both …
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Functional analysis of the Argonaute family proteins during early embryonic and germ cell development in the mouse
… serine 388 of murine protein is dependent on the MK2 and Akt/PKB pathways and regulates Ago2 localization. I created a nonphoshorylatable Ago2S388A allele to study this phosphorylation event during mouse development. Lack of Ago2 phosphorylation is dispensable for adult hematopoiesis, oogenesis, …
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Evaluating the use of surface source banking to accelerate Monte Carlo transport simulations of far-field particle fluxes
… of a test case with an OpenMC model of an MK2 TRIGA facility indicated agreement between the two criteria. Effects of oversampling a surface source that met the stationarity criteria, as well as potential limitations of the surface source banking method itself were also examined via the …
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Regulation of mRNA expression through 3’ UTR sequences of IL6 gene in amino acid-deprived HeLa cells
… after amino acid-starvation, suggesting that p38-MK2/3-TTP pathway is evidently activated and implicated in stabilization of IL6 mRNA during starvation of cancer cells. Conclusively, these studies indicate that stress signals via NF-κB and p38 lead to mRNA stabilization through 3’UTR sequences, …
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The impacts of climate change on cattle water demand and supply in Khurutshe, Botswana
… University of Waikato) based on HadCM3 and CSIRO Mk2 General Circulation Models (GCMs). Three Special Report on Emission Scenarios (SRES) are used: A1B, A1FT and A1T. These emission scenarios were selected based on their coverage for possible future Greenhouse Gas emissions (GHG). Climate …
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The Regulation of Autophagy and Its Role in Mitotic Exit
… and inhibition of tumorigenesis. We identified MK2/3 as kinases that positively regulate autophagy by phosphorylating Beclin 1 at amino acid residue serine 90. We also found that Beclin 1 serine 90 phosphorylation is negatively regulated by Bcl-2 and positively regulated by AMPK. Beclin 1 serine …
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The Investigation and Implementation of electrical Impedance Tomography Hardware System
… describes in detail the development, of the MK2 EIT system which is presented as the output of this research.
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Probing Cosmology with the MeerKAT Interferometer
… the same orders of magnitude (∼ 10−2- 10−1 Mpc3 mK2), and within 1–2 σ uncertainties of each of the two estimated power spectra. A statistically significant correlation is also observed between the visibility data and simulated visibilities, which use the detected Hi galaxies as input, and which …
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Instrumentation for low-conductivity magnetic induction tomography
… use of coil orientation. Finally, the Cardiff Mk2 multi-frequency system provided an order of magnitude improvement in measurement precision in comparison to the Cardiff Mk1 system with phase measurement precision of 1.1 mº - 8mº over 10MHz -0.5MHz, SNR for in vivo human head measurements …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… p38 is crucial for cytokine production in ILC2s. MK2 and MK3, two kinases downstream of p38, were also found to regulate production of IL-6 and IL-13. In addition to cytokine production, stimulation of ILC2 cells with IL-33 induced an increase in ILC2 size and granularity. Moreover, IL-33 …
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Studies of the mechanisms involved in host finding and mating behaviour of the African coffee white stem borer, Monochamus leuconotus (pascoe) (Cleoptera: Cerambycidae)
… and methyl salicylate. Intercept panel traps and MK2 rat traps were effective in retaining insects caught. Floral surveys conducted around coffee fields to identify alternative host plants did not give conclusive evidence on the existence of alternative host plants although suspected coffee stem …