Global ETD Search
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Showing 1 to 6 of 6 for “"MIXL1"”.
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
<p>MIXL1, an evolutionarily conserved, paired-type homeobox transcription factor induced by BMP4/TGFb signaling, is a critical regulator of embryonic and adult hematopoiesis. Several lines of evidence implicate MIXL1 in hematopoietic transformation: (i) Aberrant MIXL1 expression is seen in human …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… transcription factors Goosecoid (Gsc) and Mixl1. At the molecular level, Gsc has been described to function as a transcriptional repressor by directly binding to paired homedomain binding sites on target promoters. Here, I describe a novel mechanism of transcriptional repression by Gsc. …
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Molecular analysis of germ cell specification
… and cells expressing mesoderm markers (i.e T, Mixl1, Wnt3a). These populations are mutually exclusive, as germline markers are expressed in different cells than mesoderm markers. Moreover, commitment of cells to these fates is asynchronous, as cells expressing PGC markers appear before cells …
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Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
… factors (TFs) such as Zic2/3, Mix-like 1(Mixl1), Eomesodermin (Eomes), Stat3, and Runx1 in early development. These key TFs are involved in a variety of roles, such as metabolism, as well as the fate decision of mesoderm, and blood development. Constructing an understanding of the stepwise …
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Developing a stem-cell system of embryonic development organised by a morphogen signaling centre
… mesoderm and endoderm: SOX17, GATA6, Bra, and MIXL1 was expressed in varying levels while only gastruloids formed with a bone morphogenetic protein-4 signaling center, expressed markers for anterior neural lineages as seen by an upregulation in POU3F1, EN1, OTX2, IRX6, and SCUBE1. …
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Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… A treatment. By contrast, HHEX, CXCR4, FOXA2, MIXL1 and LIM1/LHX1 were expressed to various extents within the SOX17+ populations of each activin A treatment. These data provides novel insight in DE gene expression at the cellular level of vitro differentiated hESCs and illustrates the …