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Showing 1 to 4 of 4 for “"MIST1"”.
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Investigating the role of the basic helix-loop-helix transcription factor MIST1 in pancreatic diseases
… acinar-specific maturation transcription factor MIST1 to AP damage and organ recovery and its role in AP induced PDAC upon oncogenic transformation. Analysis of wild-type and <em>Mist1</em> conditional null mice revealed that <em>Mist1 </em>gene transcription and protein accumulation are …
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LINEAGE TRACING ANALYSIS OF PANCREATIC ACINAR CELL DE DIFFERENTIATION AND TRANS-DIFFERENTIATION IN VITRO AND IN VIVO IN THE ABSENCE OF MIST 1
… The acinar specific transcription factor MIST1 is required for acinar cell maturation and targeted deletion of Misti (Mist1'A) in mice results in incomplete maturation of acinar cells, and increased susceptibility to pancreatic injury. Previous studies revealed that the majority of …
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Establishing The Role Of The Pancreatic Transcription Factor Mist1 In Xbp1-Mediated Maintenance Of Pancreatic Acinar Cell Homeostasis
… of the acinar cell-specific transcription factor MIST1 as a downstream effector of XBP1. We verify that MIST1 is a direct target of XBP1, and a number of MIST1 target genes directly participate in facilitating cell recovery and survival during ER stress. Together, these data indicate that XBP1 and …
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Control of Neuroendocrine Cell Physiology by a Single Transcription Factor, Drosophila Basic Helix Loop Helix Regulator DIMMED
… a highly active RSP. The mouse orthologue Mist1 likewise plays a role in supporting the RSP of serous exocrine cells. This thesis has three goals. First, I evaluated a set of putative DIMM targets obtained by another scientist in the lab, and ask whether or not these are direct targets of …